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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxadrtm1Mds
targeted mutation 1, Michael D Schneider
MGI:3711225
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3711513
cn2
 		Cxadrtm1Mds/Cxadrtm1Mds
Tg(Tnnt2-cre)5Blh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3711514
cn3
 		Cxadrtm1Mds/Cxadrtm1Mds
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3711507
cn4
 		Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Myh6-cre)2182Mds/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3711512


Genotype
MGI:3711513
cn1
Allelic
Composition		 Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (15 available)
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (15 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:121400 )
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes

cardiovascular system
abnormal cardinal vein morphology ( J:121400 )
• at E10.5, engorgement of the cardinal veins is apparent
abnormal heart tube morphology ( J:121400 )
• hyperplasia of proximal heart tube is seen at E10.5
absent sinoatrial valve ( J:121400 )
• sinuatrial valves, located at the junction between sinus venosus and atrium in wild-type embryos, are absent




Genotype
MGI:3711514
cn2
Allelic
Composition		 Cxadrtm1Mds/Cxadrtm1Mds
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (15 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:121400 )
• no live conditional null mice are found at 4 weeks after birth; embryos at E10.5; mice display identical phenotype to Cxadrtm1.1Mds homozygotes

cardiovascular system
abnormal cardinal vein morphology ( J:121400 )
• at E10.5, engorgement of the cardinal veins is apparent
abnormal heart tube morphology ( J:121400 )
• hyperplasia of proximal heart tube is seen at E10.5
absent sinoatrial valve ( J:121400 )
• sinuatrial valves, located at the junction between sinus venosus and atrium in wild-type embryos, are absent




Genotype
MGI:3711507
cn3
Allelic
Composition		 Cxadrtm1Mds/Cxadrtm1Mds
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (15 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121400 )
N
• many conditional null mice are born alive and survive to adulthood (20/102)

cardiovascular system
abnormal sinoatrial valve morphology ( J:121400 )
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
abnormal heart ventricle morphology ( J:121400 )
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells




Genotype
MGI:3711512
cn4
Allelic
Composition		 Cxadrtm1Mds/Cxadrtm1.1Mds
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxadrtm1.1Mds mutation (0 available); any Cxadr mutation (15 available)
Cxadrtm1Mds mutation (0 available); any Cxadr mutation (15 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121400 )
N
• many conditional null mice are born alive and survive to adulthood (20/102)

cardiovascular system
abnormal sinoatrial valve morphology ( J:121400 )
• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice
abnormal heart ventricle morphology ( J:121400 )
• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory