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Allele Symbol Allele Name Allele ID |
Pygo2tm1.1Ssp targeted mutation 1, S Steven Potter MGI:3711233 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E9.5, lens induction is abnormal as indicated by reduced Pax6+ cells
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• at E12.5, lens reduction is more severe than any other conditional cross but not as severe as in the Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die neonatally
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• in all day-of-birth mice lenses were small or absent
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• optic cups are misshapen with abnormal retinal folds and excess mesenchyme cells
• however, retinal differentiation and retinal pigment epithelium are grossly normal
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• mild kidney development defects
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• mice are smaller late gestation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lens size is reduced comparable to Pygo2tm1Lan/Pygo2tm1.1Lan mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lens reduction is more severe that in either single cre cross but not as severe as in the Pygo2 null homozygotes
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• beginning at E9.5, lens induction is abnormal as indicated by reduced Pax6+ cells
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• at E9.5, the lens placode is thinner
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• at E12.5, the pigmented epithelium is collapsed to the center of the eye cup
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• at E12.5, lenses were small or absent
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• at E10.5, the optic pit is smaller than normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lenses were small compared to normal but not as severe as in Pygo2 null homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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