Analysis Tools
renal/urinary system
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• urinary creatinine levels are reduced relative to wild-type
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• 17.3% lower than wild-type mice
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• occasional clustering of mononuclear cells near the medullary tubular cells, indicating an inflammatory response
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• frequent dilatation and hypertrophy of collecting tubules in medullary region is observed
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• abnormalities are seen in renal cortex
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• mice display urinary space enlargement
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• mice display mesangial expansion
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• mice exhibit nodular glomerulosclerosis
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• abnormalities are seen in renal medulla
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• mice show 35.3% increased urine output over 24 hours compared to wild-type (2.3 ml vs 1.7 ml)
• heterozygous mice are normal
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homeostasis/metabolism
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• urinary creatinine levels are reduced relative to wild-type
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• salt-loading for 5 days or ANGII treatment fails to increase serum vasopressin concentration unlike similarly treated wild-type mice
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• 17.3% lower than wild-type mice
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• SCT-treated mice do not exhibit an increase in water consumption unlike in wild-type mice
• mice treated with a single dose of ANGII by intracerebroventricular injection fail to exhibit an increase in water consumption compared with similarly treated wild-type mice
• mice treated with a continuous dose of ANGII by intracerebroventricular injection exhibit a reduced increase in water consumption compared with similarly treated wild-type mice
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behavior/neurological
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• SCT-treated mice do not exhibit an increase in water consumption unlike in wild-type mice
• mice treated with a single dose of ANGII by intracerebroventricular injection fail to exhibit an increase in water consumption compared with similarly treated wild-type mice
• mice treated with a continuous dose of ANGII by intracerebroventricular injection exhibit a reduced increase in water consumption compared with similarly treated wild-type mice
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polydipsia
(
J:121376
)
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• mice show 45.5% higher water intake over 24 hours compared to wild-type (8.0 ml vs 5.5 ml)
• heterozygous mice are normal
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immune system
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• mice have increased numbers of macrophage marker F4/80-positive cells, especially in the glomerulus; this results from increased levels of E-selectin which mediates macrophage infiltration, and osteopontin which is a macrophage chemotactic factor
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• transcript levels of Il-10, TNFalpha, E-selectin and osteopontin are significantly increased compared to wild-type kidneys
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• occasional clustering of mononuclear cells near the medullary tubular cells, indicating an inflammatory response
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hematopoietic system
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• mice have increased numbers of macrophage marker F4/80-positive cells, especially in the glomerulus; this results from increased levels of E-selectin which mediates macrophage infiltration, and osteopontin which is a macrophage chemotactic factor
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