Phenotypes associated with this allele

• Allele Symbol: Prpf19^tm1Glri
• Allele Name: targeted mutation 1, Johannes Grillari
• Allele ID: MGI:3711357
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prpf19^tm1Glri/Prpf19^tm1Glri	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3712167
ht2	Prpf19^tm1Glri/Prpf19^+	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3712168

Genotype
MGI:3712167

hm1

• Allelic Composition: Prpf19^tm1Glri/Prpf19^tm1Glri
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:121379 )

• embryos die at blastocyst stage

embryo

abnormal inner cell mass apoptosis ( J:121379 )

• after a 6 days culture of an E3.5 embryo, a large number of dying cells are present

• however, embryos hatch and trophoblast cells attach normally in culture

absent inner cell mass proliferation ( J:121379 )

• inner cell mass cells fail to undergo proliferation

• after a 6 days culture of an E3.5 embryo, the overall number of cells is decreased

cellular

abnormal inner cell mass apoptosis ( J:121379 )

• after a 6 days culture of an E3.5 embryo, a large number of dying cells are present

• however, embryos hatch and trophoblast cells attach normally in culture

decreased cell proliferation ( J:121379 )

• at E3.5, cells do not grow in vivo or in vitro

absent inner cell mass proliferation ( J:121379 )

• inner cell mass cells fail to undergo proliferation

• after a 6 days culture of an E3.5 embryo, the overall number of cells is decreased

Genotype
MGI:3712168

ht2

• Allelic Composition: Prpf19^tm1Glri/Prpf19⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:121379 )

• mice have no phenotypic abnormalities