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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcyt2tm1Mbak
targeted mutation 1, Marica Bakovic
MGI:3711450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcyt2tm1Mbak/Pcyt2tm1Mbak involves: 129S6/SvEvTac * C57BL/6 MGI:3712164
ht2
 		Pcyt2tm1Mbak/Pcyt2+ involves: 129S6/SvEvTac * C57BL/6 MGI:3712165


Genotype
MGI:3712164
hm1
Allelic
Composition		 Pcyt2tm1Mbak/Pcyt2tm1Mbak
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcyt2tm1Mbak mutation (1 available); any Pcyt2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:121387 )
• mice die prior to E8.5




Genotype
MGI:3712165
ht2
Allelic
Composition		 Pcyt2tm1Mbak/Pcyt2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcyt2tm1Mbak mutation (1 available); any Pcyt2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:121387 )
N
• mice are fertile

homeostasis/metabolism
abnormal lipid homeostasis ( J:121387 )
• hepatic phospholipids fatty acid composition is remodeled such that saturated fatty acid levels are higher in the liver while polyunsaturated fatty acid levels are lower
• however, total lipid content is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory