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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm1(cre/Esr1*)Ims
targeted mutation 1, Igor M Samokhvalov
MGI:3711451
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx1tm1(cre/Esr1*)Ims/Runx1tm1(cre/Esr1*)Ims involves: C57BL/6 * CBA MGI:5316036
ht2
 		Runx1tm1(cre/Esr1*)Ims/Runx1+ either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR) MGI:3712087
cn3
 		Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims 		involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj MGI:5702485
cn4
 		Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Runx1tm1(cre/Esr1*)Ims/? 		involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj MGI:5702484


Genotype
MGI:5316036
hm1
Allelic
Composition		 Runx1tm1(cre/Esr1*)Ims/Runx1tm1(cre/Esr1*)Ims
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1(cre/Esr1*)Ims mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:182232 )
• pups develop successfully to term, but are unable to feed and die during the first day postpartum




Genotype
MGI:3712087
ht2
Allelic
Composition		 Runx1tm1(cre/Esr1*)Ims/Runx1+
Genetic
Background		 either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1(cre/Esr1*)Ims mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:121435 )
N
• heterozygotes appear normal, with no observable defects in hematopoietic system development




Genotype
MGI:5702485
cn3
Allelic
Composition		 Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
Genetic
Background		 involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2Arbr mutation (1 available); any Mapt mutation (430 available)
Runx1tm1(cre/Esr1*)Ims mutation (0 available); any Runx1 mutation (34 available)
Runx1tm3Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal mechanoreceptor morphology ( J:226826 )
• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2
• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice




Genotype
MGI:5702484
cn4
Allelic
Composition		 Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Runx1tm1(cre/Esr1*)Ims/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
Mapttm2Arbr mutation (1 available); any Mapt mutation (430 available)
Runx1tm1(cre/Esr1*)Ims mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal mechanoreceptor morphology ( J:226826 )
• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2
• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory