Phenotypes associated with this allele

• Allele Symbol: Mpp4^tm1Tili
• Allele Name: targeted mutation 1, Tiansen Li
• Allele ID: MGI:3711731
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpp4^tm1Tili/Mpp4^tm1Tili	involves: 129S/SvEv * C57BL/6	MGI:3712108

Genotype
MGI:3712108

hm1

• Allelic Composition: Mpp4^tm1Tili/Mpp4^tm1Tili
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina photoreceptor morphology ( J:121771 )

• SERCA2 receptors are increased in photoreceptor terminals

• IP₃ receptor 2 signaling intensity is increased 3-fold at the basal outer segments and decreased by about 20% at synaptic terminals

abnormal rod electrophysiology ( J:121771 )

• unexpectedly rods are more sensitive requiring only half as much light to elicit a half-maximal response

• beta wave amplitudes is decreased and implicit times increased

• defects are more pronounced in older mice

nervous system

abnormal retina photoreceptor morphology ( J:121771 )

• SERCA2 receptors are increased in photoreceptor terminals

• IP₃ receptor 2 signaling intensity is increased 3-fold at the basal outer segments and decreased by about 20% at synaptic terminals