Phenotypes associated with this allele

• Allele Symbol: Pygo2^tm1.1Xdai
• Allele Name: targeted mutation 1.1, Xing Dai
• Allele ID: MGI:3711738
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pygo2^tm1.1Xdai/Pygo2^tm1.2Xdai Tg(KRT14-cre)#Smr/0	involves: 129P2/OlaHsd * C57BL/6J * SJL/J	MGI:4889120

Genotype
MGI:4889120

cn1

• Allelic Composition: Pygo2^tm1.1Xdai/Pygo2^tm1.2Xdai; Tg(KRT14-cre)#Smr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:163218 )

♀ • mammary progenitor cells exhibit impaired expansion compared to in wild-type mice

♀ • however, mammary progenitor cell differentiation is normal

abnormal mammary gland development ( J:163218 )

♀ • at 3 weeks, mice lack terminal end buds compared with wild-type mice

♀ • at 6 weeks, ductal elongation is delayed compared to in wild-type mice

♀ • at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice

♀ • however, mammary progenitor cell differentiation is normal

abnormal branching of the mammary ductal tree ( J:163218 )

♀ • at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice

abnormal mammary gland embryonic development ( J:163218 )

♀ • in some newborn mice exhibit impaired mammary gland development compared with wild-type mice

abnormal mammary gland growth during lactation ( J:163218 )

♀ • during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

abnormal mammary gland growth during pregnancy ( J:163218 )

♀ • during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

lactation failure ( J:163218 )

♀

integument

decreased mammary gland epithelial cell proliferation ( J:163218 )

♀ • mammary progenitor cells exhibit impaired expansion compared to in wild-type mice

♀ • however, mammary progenitor cell differentiation is normal

abnormal mammary gland development ( J:163218 )

♀ • at 3 weeks, mice lack terminal end buds compared with wild-type mice

♀ • at 6 weeks, ductal elongation is delayed compared to in wild-type mice

♀ • at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice

♀ • however, mammary progenitor cell differentiation is normal

abnormal branching of the mammary ductal tree ( J:163218 )

♀ • at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice

abnormal mammary gland embryonic development ( J:163218 )

♀ • in some newborn mice exhibit impaired mammary gland development compared with wild-type mice

abnormal mammary gland growth during lactation ( J:163218 )

♀ • during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

abnormal mammary gland growth during pregnancy ( J:163218 )

♀ • during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

lactation failure ( J:163218 )

♀

reproductive system

abnormal mammary gland growth during pregnancy ( J:163218 )

♀ • during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

cellular

decreased mammary gland epithelial cell proliferation ( J:163218 )

♀ • mammary progenitor cells exhibit impaired expansion compared to in wild-type mice

♀ • however, mammary progenitor cell differentiation is normal