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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ighm-Ctla4Ig/Cd80)1Jbs
transgene insertion 1, Jeffery Bluestone
MGI:3711772
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0 		involves: 129S4/SvJae * FVB/N * NOD MGI:3714277
tg2
 		Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0 involves: FVB/N MGI:3714275
tg3
 		Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0 NOD.FVB-Tg(Ighm-Ctla4Ig/Cd80)1Jbs MGI:3714276


Genotype
MGI:3714277
cx1
Allelic
Composition		 Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (12 available); any Cd80 mutation (44 available)
Cd86tm2Shr mutation (3 available); any Cd86 mutation (39 available)
Tg(Ighm-Ctla4Ig/Cd80)1Jbs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
insulitis ( J:113109 )
• mice show less insulitis compared to non-transgenic double nulls
decreased regulatory T cell number ( J:113109 )
• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls
decreased susceptibility to autoimmune diabetes ( J:113109 )
• mice show 40% suppression of diabetes development compared to non-transgenic double null animals

hematopoietic system
decreased regulatory T cell number ( J:113109 )
• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls

endocrine/exocrine glands
insulitis ( J:113109 )
• mice show less insulitis compared to non-transgenic double nulls




Genotype
MGI:3714275
tg2
Allelic
Composition		 Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113109 )
N
• B and T cells develop normally in transgenic mice; peripheral B and T cells show similar development and function to polyclonasl stimuli like LPS, anti-IgM, anti-CD3 and anti-CD28 as wild-type cells
abnormal B cell physiology ( J:113109 )
• B cells from mutants inhibit proliferation and cytokine production by wild-type T cells in culture

hematopoietic system
abnormal B cell physiology ( J:113109 )
• B cells from mutants inhibit proliferation and cytokine production by wild-type T cells in culture




Genotype
MGI:3714276
tg3
Allelic
Composition		 Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic
Background		 NOD.FVB-Tg(Ighm-Ctla4Ig/Cd80)1Jbs
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113109 )
N
• no differences in insulin autoantibody responses are observed compared to NOD controls at 5, 10, 20, or 30 weeks
decreased susceptibility to autoimmune diabetes ( J:113109 )
• diabetes incidence in mice is 33% by 30 weeks of age, compared to 70% in NOD controls; mice display 25% incidence of diabetes by 19 weeks of age, compared to the same incidence by 12.2 weeks in NOD controls




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory