All Phenotypes Hdac2<Gt(W035F03)Joe> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	involves: 129S2/SvPas	MGI:4357789
hm2	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	Not Specified	MGI:3712862
cx3	Apc^Min/Apc⁺ Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	involves: 129S2/SvPas * C57BL/6J	MGI:4357790
cx4	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe} Tg(Myh6-Hod)3Joe/?	Not Specified	MGI:3712915

Allelic Composition	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2^{Gt(W035F03)Joe} mutation (0 available); any Hdac2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:152134 )

• half the expected number of homozygotes survive until weaning due to decreased birth rates and cannibalism of small homozygote pups

embryonic lethality during organogenesis, incomplete penetrance ( J:152134 )

• about 18% of E10-E13.5 embryos are homozygotes instead of the expected 25%

growth/size/body

decreased body weight ( J:152134 )

• the weight of mutant mice is reduced about 40% with low body weight persisting throughout the lifespan of the mice

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:152134 )

• thickness of intestines are reduced by about a third

abnormal large intestine crypts of Lieberkuhn morphology ( J:152134 )

• the number of cells in colon crypts are reduced by about a third

decreased intestine length ( J:152134 )

• intestines are smaller in length

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:152134 )

• the number of cells in colon crypts are reduced by about a third

small testis ( J:152134 )

• testis weight is decreased by 25% compared to controls

homeostasis/metabolism

insensitivity to growth hormone ( J:152134 )

• embryonic fibroblasts are insensitive to the anti-apoptotic effects of IGF-1

nervous system

decreased brain weight ( J:152134 )

• brain weight is decreased by 25% compared to controls

reproductive system

small testis ( J:152134 )

• testis weight is decreased by 25% compared to controls

skeleton

abnormal pelvic girdle bone morphology ( J:152134 )

• hip bones are smaller than controls

small vertebrae ( J:152134 )

• vertebrae are smaller than controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:121697 )

• nearly half of all pups born die within the first 25 postnatal days

prenatal lethality, incomplete penetrance ( J:121697 )

• some intrauterine loss of pups and occasional resorbing is observed between E12.5 and E17.5

cardiovascular system

cardiovascular system phenotype ( J:121697 )

N	• hearts function normally and isoproterenol treatment fails to induce cardiac hypertrophy as it does in wild-type mice

abnormal cardiovascular system morphology ( J:121697 )

abnormal myocardium layer morphology ( J:121697 )

abnormal myocardial fiber morphology ( J:121697 )

• cardiac myocytes exhibit an increased number of mitochondria and abnormal sarcomere structure at P10; sarcomere length is reduced while Z-bands appear broad and fuzzy

• however, structural changes are largely resolved by P65

abnormal myocardial trabeculae morphology ( J:121697 )

• despite being born with normal hearts, mice have reduced trabeculation through P8

thick myocardium compact layer ( J:121697 )

• despite being born with normal hearts, mice have thickened myocardial compact zones through P8

enlarged heart ( J:121697 )

• at P8, mice exhibit enlarged hearts relative to their reduced body size

• however, by two months hearts are normal size

thick ventricular wall ( J:121697 )

• at P8, mice exhibit thickened ventricular walls and decreased ventricular cavity size

abnormal cardiovascular system physiology ( J:121697 )

increased fetal cardiomyocyte proliferation ( J:121697 )

• proliferation is elevated starting at E15.5 and is more apparent at P2

behavior/neurological

lethargy ( J:121697 )

• at P10

• however, by two months mice are indistinguishable from wild-type

growth/size/body

enlarged heart ( J:121697 )

• at P8, mice exhibit enlarged hearts relative to their reduced body size

• however, by two months hearts are normal size

decreased body size ( J:121697 )

• at P10, mice are smaller

• however, by two months mice are indistinguishable from wild-type

muscle

abnormal myocardium layer morphology ( J:121697 )

abnormal myocardial fiber morphology ( J:121697 )

• cardiac myocytes exhibit an increased number of mitochondria and abnormal sarcomere structure at P10; sarcomere length is reduced while Z-bands appear broad and fuzzy

• however, structural changes are largely resolved by P65

abnormal myocardial trabeculae morphology ( J:121697 )

• despite being born with normal hearts, mice have reduced trabeculation through P8

thick myocardium compact layer ( J:121697 )

• despite being born with normal hearts, mice have thickened myocardial compact zones through P8

increased fetal cardiomyocyte proliferation ( J:121697 )

• proliferation is elevated starting at E15.5 and is more apparent at P2

diffuse Z line ( J:121697 )

• sarcomeres in cardiac myocytes have broad and fuzzy Z-bands

cellular

increased fetal cardiomyocyte proliferation ( J:121697 )

• proliferation is elevated starting at E15.5 and is more apparent at P2

Allelic Composition	Apc^Min/Apc⁺ Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Hdac2^{Gt(W035F03)Joe} mutation (0 available); any Hdac2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased small intestine adenocarcinoma incidence ( J:152134 )

• intestinal adenocarcinoma occurs in these mice though not to the extent as in Apc^Min controls

decreased tumor incidence ( J:152134 )

• mice develop fewer intestinal tumors than Apc^Min controls

• the small intestine of female mice had 60% fewer tumors than controls

• mice fail to develop tumors in the colon while they are occasionally found in the colon of Apc^Min controls

digestive/alimentary system

increased small intestine adenocarcinoma incidence ( J:152134 )

• intestinal adenocarcinoma occurs in these mice though not to the extent as in Apc^Min controls

Allelic Composition	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe} Tg(Myh6-Hod)3Joe/?
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2^{Gt(W035F03)Joe} mutation (0 available); any Hdac2 mutation (40 available)
Tg(Myh6-Hod)3Joe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

enlarged heart ( J:121697 )

• at 4 weeks, mice have an increased heart to body weight ratios

cardiac hypertrophy ( J:121697 )

• at 8 weeks, mice exhibit increasing cardiac hypertrophy

growth/size/body

enlarged heart ( J:121697 )

• at 4 weeks, mice have an increased heart to body weight ratios

cardiac hypertrophy ( J:121697 )

• at 8 weeks, mice exhibit increasing cardiac hypertrophy

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