Analysis Tools
reproductive system
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• increase in apoptosis with age
• remaining sperm are abnormal
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• although numbers are initially normal the number of male germ cells decrease with time
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• spermatocytes do not proceed passed meiosis I and fail to progress to pachytene
• while 80% of spermatocyte chromosomes are condensed the remaining 20% have an 'exploded' morphology with scattered chromatin
• sex bodies fail to form
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• increase in apoptosis levels with age
• tubules lacking germ cells but containing Sertoli cells are apparent at 3 months of age
• however, Sertoli cells are normal
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small testis
(
J:120824
)
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• despite being of similar size at P10, a few days later mice have smaller testis
• testes degenerate with age
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• male mice are infertile
• however, females are fertile
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endocrine/exocrine glands
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• increase in apoptosis levels with age
• tubules lacking germ cells but containing Sertoli cells are apparent at 3 months of age
• however, Sertoli cells are normal
|
small testis
(
J:120824
)
|
|
• despite being of similar size at P10, a few days later mice have smaller testis
• testes degenerate with age
|
cellular
|
|
• increase in apoptosis with age
• remaining sperm are abnormal
|
|
|
• although numbers are initially normal the number of male germ cells decrease with time
|
|
|
• spermatocytes do not proceed passed meiosis I and fail to progress to pachytene
• while 80% of spermatocyte chromosomes are condensed the remaining 20% have an 'exploded' morphology with scattered chromatin
• sex bodies fail to form
|
