Phenotypes associated with this allele

• Allele Symbol: Ube2n^{Gt(OST374154)Lex}
• Allele Name: gene trap OST374154, Lexicon Genetics
• Allele ID: MGI:3712183
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2n^Gt(OST374154)Lex/Ube2n^Gt(OST374154)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3712577
ht2	Ube2n^Gt(OST374154)Lex/Ube2n^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:3712578

Genotype
MGI:3712577

hm1

• Allelic Composition: Ube2n^{Gt(OST374154)Lex}/Ube2n^{Gt(OST374154)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:120846 )

• probably die before E5.5

Genotype
MGI:3712578

ht2

• Allelic Composition: Ube2n^{Gt(OST374154)Lex}/Ube2n⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

immune system

abnormal leukocyte physiology ( J:120846 )

• LPS-stimulated cultured splenocytes produce significantly less TNF, IL-6, and INFG

• however, no difference in lymphocyte populations is seen in the bone marrow, spleen, or thymus compared to wild-type mice

decreased B cell proliferation ( J:120846 )

• partial defect in response to anti-IgM or LPS stimulation

decreased T cell proliferation ( J:120846 )

• partial defect in response to anti-CD3, anti-CD28 stimulation

abnormal macrophage physiology ( J:120846 )

• LPS-stimulated cultured macrophages produce significantly less TNF, IL-6, and INFG

• decrease in LPS-induced cytokine production is more striking in macrophages than in splenocytes

decreased susceptibility to endotoxin shock ( J:120846 )

• about half as many mice die following a challenge with 250 mg/kg LPS compared to wild-type mice

hematopoietic system

abnormal leukocyte physiology ( J:120846 )

• LPS-stimulated cultured splenocytes produce significantly less TNF, IL-6, and INFG

• however, no difference in lymphocyte populations is seen in the bone marrow, spleen, or thymus compared to wild-type mice

decreased B cell proliferation ( J:120846 )

• partial defect in response to anti-IgM or LPS stimulation

decreased T cell proliferation ( J:120846 )

• partial defect in response to anti-CD3, anti-CD28 stimulation

abnormal macrophage physiology ( J:120846 )

• LPS-stimulated cultured macrophages produce significantly less TNF, IL-6, and INFG

• decrease in LPS-induced cytokine production is more striking in macrophages than in splenocytes

cellular

decreased B cell proliferation ( J:120846 )

• partial defect in response to anti-IgM or LPS stimulation

decreased T cell proliferation ( J:120846 )

• partial defect in response to anti-CD3, anti-CD28 stimulation