Phenotypes associated with this allele

• Allele Symbol: Fcer1a^tm1Ftl
• Allele Name: targeted mutation 1, Fu-Tong Liu
• Allele ID: MGI:3712201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcer1a^tm1Ftl/Fcer1a^tm1Ftl	CBy.129S2-Fcer1a^tm1Ftl	MGI:3712655

Genotype
MGI:3712655

hm1

• Allelic Composition: Fcer1a^tm1Ftl/Fcer1a^tm1Ftl
• Genetic Background: CBy.129S2-Fcer1a^tm1Ftl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:120702 )

• the number of infiltrating eosinophils in lungs after antigen challenge with or without adjuvant is significantly lower than in wild-type

• eosinophil infiltrationis lower in perivascular areas in the lung after antigen challenge

abnormal mast cell physiology ( J:120702 )

• bone marrow-derived mouse mast cells (BMMC) lack IgE binding and fail to elicit any IgE-dependent mast cell responses in vivo

decreased circulating interleukin-4 level ( J:120702 )

• after antigen challenge with or without adjuvant, Il-4 levels are significantly lower than in wild-type

abnormal humoral immune response ( J:120702 )

• airway hyperresponsiveness to airway antigen challenge is reduced with or without treatment with anti-Il-5 antibodies

hematopoietic system

decreased eosinophil cell number ( J:120702 )

• the number of infiltrating eosinophils in lungs after antigen challenge with or without adjuvant is significantly lower than in wild-type

• eosinophil infiltrationis lower in perivascular areas in the lung after antigen challenge

abnormal mast cell physiology ( J:120702 )

• bone marrow-derived mouse mast cells (BMMC) lack IgE binding and fail to elicit any IgE-dependent mast cell responses in vivo

homeostasis/metabolism

decreased circulating interleukin-4 level ( J:120702 )

• after antigen challenge with or without adjuvant, Il-4 levels are significantly lower than in wild-type