Phenotypes associated with this allele

• Allele Symbol: Adora1^tm1Rgrn
• Allele Name: targeted mutation 1, Robert W Greene
• Allele ID: MGI:3712214
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora1^tm1Rgrn/Adora1^tm1Rgrn	involves: 129S4/SvJae * C57BL/6	MGI:3712652
cn2	Adora1^tm1Rgrn/Adora1^tm1Rgrn	involves: 129S4/SvJae * C57BL/6	MGI:3712653

Genotype
MGI:3712652

hm1

• Allelic Composition: Adora1^tm1Rgrn/Adora1^tm1Rgrn
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:120655 )

• mice are normal

Genotype
MGI:3712653

cn2

• Allelic Composition: Adora1^tm1Rgrn/Adora1^tm1Rgrn
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal nervous system electrophysiology ( J:120655 )

• injection of AAV-Cre removes the neo cassette and results in a null allele

• following injection of AAV-Cre, 7 of 9 CA1 pyramidal neurons are unresponsive to adenosine stimulation

• however, the action potential threshold duration and amplitude, resting potential and input resistance following adenosine stimulation are no different between unresponsive and responsive neurons

abnormal excitatory postsynaptic potential ( J:120655 )

• fEPSP is reduced to 40% of its baseline amplitude in regions contralateral to AAV-Cre injection following adenosine stimulation

• AAV-Cre-induced reduction in A1 receptors in CA3 neurons abolishes all adenosine affects