All Phenotypes Igh<tm1Mnz> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1Mnz/Igh^tm1Mnz	B6.129P2-Igh^tm1Mnz	MGI:3712642
cn2	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:6695985
cn3	Commd8^tm1.1Ksuz/Commd8^tm1.1Ksuz Igh^tm1Mnz/Igh⁺ Cd79a^tm1(cre)Reth/Cd79a⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL	MGI:6358358
cx4	H2ax^tm1Nus/H2ax^tm1Nus Igh^tm1Mnz/Igh^tm1Mnz	involves: 129P2/OlaHsd	MGI:3712649
cx5	Igh^tm1Mnz/Igh^tm1Mnz Lyn^tm1Sor/Lyn^tm1Sor	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:3712645
cx6	Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn Igh^tm1Mnz/Igh^tm1Mnz	involves: 129P2/OlaHsd * C57BL/6	MGI:3714748

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• some mutant B cells that express Ig lambda differentiate into short-lived plasmacytes in red pulp of lymphoid follicles; plasmacyte response is greater than in Igh^tm2Mnz cells or wild-type

• fraction of mutant B cells differentiate into short lived germinal center (GC) cells; GC response is greater than in Igh^tm2Mnz cells

• when equal numbers of Igh^tm1Mnz and Igh^tm2Mnz B cells are transferred to wild-type recipient mice, after immunization with NP-Ficoll, Igh^tm1Mnz B cells preferentially expand and proliferation to make up ~46% of Ig lambda B cells whereas Igh^tm2Mnz B cells are not expanded

• after 5 days post immunization, 85% of plasmacytes and 60% of germinal center cells are Igh^tm1Mnz B cells (high affinity)

• mutant B cells with high affinity for antigen are preferentially selected during early phase of T1-2 immune response, over mutant B cells with low affinity for antigen

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

cellular

abnormal cell cycle ( J:75653 )

• absolute number of cells in cell cycle is always higher than in Igh^tm2Mnz or wild-type mice

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

hematopoietic system

abnormal B cell physiology ( J:75653 )

• some mutant B cells that express Ig lambda differentiate into short-lived plasmacytes in red pulp of lymphoid follicles; plasmacyte response is greater than in Igh^tm2Mnz cells or wild-type

• fraction of mutant B cells differentiate into short lived germinal center (GC) cells; GC response is greater than in Igh^tm2Mnz cells

• after 5 days post immunization, 85% of plasmacytes and 60% of germinal center cells are Igh^tm1Mnz B cells (high affinity)

• mutant B cells with high affinity for antigen are preferentially selected during early phase of T1-2 immune response, over mutant B cells with low affinity for antigen

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

Allelic Composition	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Uba mutation (0 available); any Aicda mutation (57 available)
Dis3^tm1.1Uba mutation (0 available); any Dis3 mutation (43 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

hematopoietic system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

Allelic Composition	Commd8^tm1.1Ksuz/Commd8^tm1.1Ksuz Igh^tm1Mnz/Igh⁺ Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Commd8^tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen B cell follicle morphology ( J:278399 )

• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells

• however, B cells are distributed at the B-T boundary after 6 hours

hematopoietic system

abnormal spleen B cell follicle morphology ( J:278399 )

• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells

• however, B cells are distributed at the B-T boundary after 6 hours

Allelic Composition	H2ax^tm1Nus/H2ax^tm1Nus Igh^tm1Mnz/Igh^tm1Mnz
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2ax^tm1Nus mutation (1 available); any H2ax mutation (7 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:120658 )

N	• the rate of somatic hypermutation is normal

Allelic Composition	Igh^tm1Mnz/Igh^tm1Mnz Lyn^tm1Sor/Lyn^tm1Sor
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)
Lyn^tm1Sor mutation (2 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn Igh^tm1Mnz/Igh^tm1Mnz
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Igh^tm2Mnz mice or CD19-null Igh^tm1Mnz mice

hematopoietic system

abnormal B cell physiology ( J:75653 )

• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Igh^tm2Mnz mice or CD19-null Igh^tm1Mnz mice

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