All Phenotypes Igh<tm1Mnz> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1Mnz/Igh^tm1Mnz	B6.129P2-Igh^tm1Mnz	MGI:3712642
cn2	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:6695985
cn3	Commd8^tm1.1Ksuz/Commd8^tm1.1Ksuz Igh^tm1Mnz/Igh⁺ Cd79a^tm1(cre)Reth/Cd79a⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL	MGI:6358358
cx4	H2ax^tm1Nus/H2ax^tm1Nus Igh^tm1Mnz/Igh^tm1Mnz	involves: 129P2/OlaHsd	MGI:3712649
cx5	Igh^tm1Mnz/Igh^tm1Mnz Lyn^tm1Sor/Lyn^tm1Sor	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:3712645
cx6	Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn Igh^tm1Mnz/Igh^tm1Mnz	involves: 129P2/OlaHsd * C57BL/6	MGI:3714748

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• some mutant B cells that express Ig lambda differentiate into short-lived plasmacytes in red pulp of lymphoid follicles; plasmacyte response is greater than in Igh^tm2Mnz cells or wild-type

• fraction of mutant B cells differentiate into short lived germinal center (GC) cells; GC response is greater than in Igh^tm2Mnz cells

• when equal numbers of Igh^tm1Mnz and Igh^tm2Mnz B cells are transferred to wild-type recipient mice, after immunization with NP-Ficoll, Igh^tm1Mnz B cells preferentially expand and proliferation to make up ~46% of Ig lambda B cells whereas Igh^tm2Mnz B cells are not expanded

• after 5 days post immunization, 85% of plasmacytes and 60% of germinal center cells are Igh^tm1Mnz B cells (high affinity)

• mutant B cells with high affinity for antigen are preferentially selected during early phase of T1-2 immune response, over mutant B cells with low affinity for antigen

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

cellular

abnormal cell cycle ( J:75653 )

• absolute number of cells in cell cycle is always higher than in Igh^tm2Mnz or wild-type mice

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

hematopoietic system

abnormal B cell physiology ( J:75653 )

• some mutant B cells that express Ig lambda differentiate into short-lived plasmacytes in red pulp of lymphoid follicles; plasmacyte response is greater than in Igh^tm2Mnz cells or wild-type

• fraction of mutant B cells differentiate into short lived germinal center (GC) cells; GC response is greater than in Igh^tm2Mnz cells

• after 5 days post immunization, 85% of plasmacytes and 60% of germinal center cells are Igh^tm1Mnz B cells (high affinity)

• mutant B cells with high affinity for antigen are preferentially selected during early phase of T1-2 immune response, over mutant B cells with low affinity for antigen

increased B cell apoptosis ( J:75653 )

• there are higher numbers of apoptotic mutant B cells than in wild-type or Igh^tm2Mnz B cells in spleens 3 and 5 days after immunization

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 25% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a much higher percentage of high-affinity B cells (58%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in Igh^tm2Mnz B cells or wild-type

Allelic Composition	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Uba mutation (0 available); any Aicda mutation (56 available)
Dis3^tm1.1Uba mutation (0 available); any Dis3 mutation (42 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

hematopoietic system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

Allelic Composition	Commd8^tm1.1Ksuz/Commd8^tm1.1Ksuz Igh^tm1Mnz/Igh⁺ Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Commd8^tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen B cell follicle morphology ( J:278399 )

• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells

• however, B cells are distributed at the B-T boundary after 6 hours

hematopoietic system

abnormal spleen B cell follicle morphology ( J:278399 )

• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells

• however, B cells are distributed at the B-T boundary after 6 hours

Allelic Composition	H2ax^tm1Nus/H2ax^tm1Nus Igh^tm1Mnz/Igh^tm1Mnz
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2ax^tm1Nus mutation (1 available); any H2ax mutation (7 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:120658 )

N	• the rate of somatic hypermutation is normal

Allelic Composition	Igh^tm1Mnz/Igh^tm1Mnz Lyn^tm1Sor/Lyn^tm1Sor
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)
Lyn^tm1Sor mutation (2 available); any Lyn mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

hematopoietic system

abnormal B cell physiology ( J:75653 )

• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Igh^tm1Mnz mice

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

cellular

increased B cell proliferation ( J:75653 )

• antigen-specific B cell proliferation is enhanced compared to Igh^tm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)

• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn Igh^tm1Mnz/Igh^tm1Mnz
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (58 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:75653 )

• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Igh^tm2Mnz mice or CD19-null Igh^tm1Mnz mice

hematopoietic system

abnormal B cell physiology ( J:75653 )

• B cells show no response to NP-Ficoll immunization compared to wild-type CD19 Igh^tm2Mnz mice or CD19-null Igh^tm1Mnz mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24