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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cyp19a1-cre)5912Gle
transgene insertion 5912, Gustavo Leone
MGI:3712298
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Cyp19a1-cre)5912Gle/0 		involves: 129S6/SvEvTac * FVB/N MGI:5473266


Genotype
MGI:5473266
cn1
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Cyp19a1-cre)5912Gle/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Tg(Cyp19a1-cre)5912Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:183999 )
• no live mutant embryos are recovered after E10.5

growth/size/body
embryonic growth retardation ( J:183999 )
• displayed by live embryos at E10.5

embryo
embryonic growth retardation ( J:183999 )
• displayed by live embryos at E10.5
abnormal embryonic tissue morphology ( J:183999 )
• significant numbers of apoptotic cells are detected in branchial arches at E10.5
abnormal placenta morphology ( J:183999 )
• embryos show collapsed labyrinth-like placental architecture

cardiovascular system
hemorrhage ( J:183999 )
• observed at E10.5 along with vascular dilation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory