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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Hod)3Joe
transgene insertion 3, Jonathan Epstein
MGI:3712794
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe
Tg(Myh6-Hod)3Joe/?
Not Specified MGI:3712915
tg2
Tg(Myh6-Hod)3Joe/? Not Specified MGI:3712910


Genotype
MGI:3712915
cx1
Allelic
Composition
Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe
Tg(Myh6-Hod)3Joe/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2Gt(W035F03)Joe mutation (0 available); any Hdac2 mutation (40 available)
Tg(Myh6-Hod)3Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 4 weeks, mice have an increased heart to body weight ratios
• at 8 weeks, mice exhibit increasing cardiac hypertrophy

growth/size/body
• at 4 weeks, mice have an increased heart to body weight ratios
• at 8 weeks, mice exhibit increasing cardiac hypertrophy




Genotype
MGI:3712910
tg2
Allelic
Composition
Tg(Myh6-Hod)3Joe/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 32 weeks

cardiovascular system
• hypertrophied myocytes
• heart to body weight ratio is increased about 25%
• mice exhibit increasing cardiac hypertrophy (J:121677)
• as early a 3 weeks after birth (J:121995)
• severe concentric left and right ventricular hypertrophy that progressed variably to cardiac dilatation accompanied by heart failure
• at time of death
• 5+/-1mmHg compared to 2+/-0.3mmHg in wild-type mice
• impaired diastolic relaxation with no change in systolic blood pressure
• some mice experience heart failure

muscle
• hypertrophied myocytes

growth/size/body
• heart to body weight ratio is increased about 25%
• mice exhibit increasing cardiac hypertrophy (J:121677)
• as early a 3 weeks after birth (J:121995)





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory