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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lbx2tm1Fchn
targeted mutation 1, Fabian Chen
MGI:3712795
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lbx2tm1Fchn/Lbx2tm1Fchn B6.129-Lbx2tm1Fchn MGI:3712863
hm2
 		Lbx2tm1Fchn/Lbx2tm1Fchn involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6460288
cx3
 		Lbx2tm1Fchn/Lbx2tm1Fchn
Pax3Sp/Pax3Sp 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3712864


Genotype
MGI:3712863
hm1
Allelic
Composition		 Lbx2tm1Fchn/Lbx2tm1Fchn
Genetic
Background		 B6.129-Lbx2tm1Fchn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2tm1Fchn mutation (0 available); any Lbx2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121890 )
N
• a decrease in expected ratio of 4-week old mice is observed but is not statistically significant on either background




Genotype
MGI:6460288
hm2
Allelic
Composition		 Lbx2tm1Fchn/Lbx2tm1Fchn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2tm1Fchn mutation (0 available); any Lbx2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121890 )
• a decrease in expected ratio of 4-week old mice is observed but is not statistically significant on either background




Genotype
MGI:3712864
cx3
Allelic
Composition		 Lbx2tm1Fchn/Lbx2tm1Fchn
Pax3Sp/Pax3Sp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx2tm1Fchn mutation (0 available); any Lbx2 mutation (11 available)
Pax3Sp mutation (4 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:121890 )
• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5
exencephaly ( J:121890 )
• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5
abnormal cranial ganglia morphology ( J:121890 )
• Lbx2 expression is significantly decreased with Pax3 deficiency
abnormal dorsal root ganglion morphology ( J:121890 )
• Lbx2 expression is significantly decreased with Pax3 deficiency

homeostasis/metabolism
edema ( J:121890 )
• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5

embryo
open neural tube ( J:121890 )
• defects seen with Pax3 homozygosity are not affected by Lbx2-deficiency at E10.5-13.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory