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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Engtm2.2Hma
targeted mutation 2.2, Helen M Arthur
MGI:3712803
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Engtm2.2Hma/Engtm2.2Hma involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3712890


Genotype
MGI:3712890
hm1
Allelic
Composition		 Engtm2.2Hma/Engtm2.2Hma
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.2Hma mutation (0 available); any Eng mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:121898 )
• similar numbers of homozygotes and wild-type embryos are seen at 9.5 dpc, but no homozygotes are born alive

embryo
abnormal vitelline vasculature morphology ( J:121898 )
• at 9.5 dpc, angiogenesis defects in yolk sac are observed, contrasting to normal yolk sac of wild-type embryos
abnormal embryo development ( J:121898 )
• authors state than embryos die mid-embryogenesis with phenotype indistinguishable from Engtm1Hma homozygotes

cardiovascular system
abnormal vitelline vasculature morphology ( J:121898 )
• at 9.5 dpc, angiogenesis defects in yolk sac are observed, contrasting to normal yolk sac of wild-type embryos




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory