Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pygo2tm1.2Ssp targeted mutation 1.2, S Steven Potter MGI:3712856 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E9.5, lens induction is abnormal as indicated by reduced Pax6+ cells
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• at E12.5, lens reduction is more severe than any other conditional cross but not as severe as in the Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are born but with rare exceptions die shortly afterwards
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• at high penetrance
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• at E18.5, mesenchyme surrounding the ureteric buds is thickened 30% and ureteric tips are dilated and misshaped
• however, nephrogenesis is normal
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• at low penetrance
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• at high penetrance
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• at high penetrance
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• at low penetrance
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• at low penetrance
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• at low penetrance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lens size is reduced comparable to Pygo2tm1Lan/Pygo2tm1.1Lan mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lens reduction is more severe that in either single cre cross but not as severe as in the Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, lenses were small compared to normal but not as severe as in Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the lens size is smaller than normal but not statistically different from that in Pygo2 null homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Small size, eye defects and exencephaly in Pygo1tm1.1Ssp/Pygo1tm1.1Ssp Pygo2tm1.2Ssp/Pygo2tm1.2Ssp mice at E18.5
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• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity
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• ureteric bud numbers are decreased 25% in mice with kidney defects
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• retinas are absent or rudimentary and the pigmented retina is folded
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• the pigmented retina is folded
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• mice have phenotypes similar to Pygo2tm1.1Ssp single homozygotes and no synergy is observed in defect penetrance or severity
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• seen in a small percentage of fetuses
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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