Phenotypes associated with this allele

• Allele Symbol: Irak4^tm1Gram
• Allele Name: targeted mutation 1, Hermann Gram
• Allele ID: MGI:3712883
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak4^tm1Gram/Irak4^tm1Gram	involves: BALB/c	MGI:3713242

Genotype
MGI:3713242

hm1

• Allelic Composition: Irak4^tm1Gram/Irak4^tm1Gram
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:121912 )

• Il-1 receptor/TLR7-mediated production of cytokines is largely absent from MEFs

abnormal chemokine secretion ( J:121912 )

• Il-1 receptor/TLR7-mediated production of chemokines is largely absent from MEFs

cellular

abnormal fibroblast physiology ( J:121912 )

• mouse embryonic fibroblasts (MEFs) show defective activation of NF kappa B, JNK, and p38 in response to Il-1beta or TLR7 ligand

• induction of Il-1beta-responsive genes is nearly ablated