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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akap10Gt(RRC139)Byg
gene trap RRC139, BayGenomics
MGI:3712925
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akap10Gt(RRC139)Byg/Akap10Gt(RRC139)Byg involves: 129P2/OlaHsd MGI:3713129
hm2
 		Akap10Gt(RRC139)Byg/Akap10Gt(RRC139)Byg involves: 129P2/OlaHsd * FVB/N MGI:3713131
ht3
 		Akap10Gt(RRC139)Byg/Akap10+ involves: 129P2/OlaHsd MGI:3713130
ht4
 		Akap10Gt(RRC139)Byg/Akap10+ involves: 129P2/OlaHsd * FVB/N MGI:3713132


Genotype
MGI:3713129
hm1
Allelic
Composition		 Akap10Gt(RRC139)Byg/Akap10Gt(RRC139)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap10Gt(RRC139)Byg mutation (1 available); any Akap10 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:121838 )
• Background Sensitivity: on a 129P2/OlaHsd background, 50% of mice die within 1 year; mortality is observed only in adult animals

cardiovascular system
abnormal sinus arrhythmia ( J:121838 )
• at greater than 10 weeks of age, unstressed mice show pronounced sinus arrhythmia
increased heart rate variability ( J:121838 )
• unstressed mice older than 10 weeks have abnormally high beat-to-beat heart rate variability (HRV)
decreased heart rate ( J:121838 )
• treatment of mice with cholinergic agonists results in greater slowing of heart rate compared to wild-type at more than 10 weeks of age
abnormal sinoatrial node conduction ( J:121838 )
• mice show sinus pauses with junctional escape beats at a 40-fold increased frequency compared to wild-type (preceded by sinus slowing with prolonged P-P wave interval)
abnormal P wave ( J:121838 )
• mutants exhibit 3 vs 0.2 in wild-type nonconductive P waves/hour (AV heartblock)

nervous system
abnormal baroreceptor physiology ( J:121838 )
• mice display stronger baroreflexes upon activation of vagus nerve with phenylephrine




Genotype
MGI:3713131
hm2
Allelic
Composition		 Akap10Gt(RRC139)Byg/Akap10Gt(RRC139)Byg
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap10Gt(RRC139)Byg mutation (1 available); any Akap10 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121838 )
N
• Background Sensitivity: no early (<1 year) lethality is seen on this background




Genotype
MGI:3713130
ht3
Allelic
Composition		 Akap10Gt(RRC139)Byg/Akap10+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap10Gt(RRC139)Byg mutation (1 available); any Akap10 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:121838 )
• Background Sensitivity: on a 129P2/OlaHsd background, 25% of mice die within 1 year; mortality is observed only in adult animals

cardiovascular system
decreased heart rate ( J:121838 )
• treatment of mice with cholinergic agonists results in greater slowing of heart rate compared to wild-type




Genotype
MGI:3713132
ht4
Allelic
Composition		 Akap10Gt(RRC139)Byg/Akap10+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap10Gt(RRC139)Byg mutation (1 available); any Akap10 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121838 )
N
• Background Sensitivity: no early (<1 year) lethality is seen on this background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory