Phenotypes associated with this allele

• Allele Symbol: Hes1^tm1Hojo
• Allele Name: targeted mutation 1, Masato Hojo
• Allele ID: MGI:3712941
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Ito/Emx1^+ Hes1^tm1Fgu/Hes1^tm1Hojo Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3713199

Genotype
MGI:3713199

cn1

• Allelic Composition: Emx1^tm1(cre)Ito/Emx1⁺; Hes1^tm1Fgu/Hes1^tm1Hojo; Hes5^tm1Fgu/Hes5^tm1Fgu
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pituitary gland morphology ( J:121843 )

• pituitary gland is sphere-shaped

• gland is composed of round cells only and lacks columnar cells

• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC

increased somatotroph cell number ( J:121843 )

• growth hormone-producing cells are slightly increased in number

abnormal neurohypophysis morphology ( J:121843 )

• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals

abnormal pituitary infundibular stalk morphology ( J:121843 )

• at E12.5, evagination of the infundibulum is affected compared to control embryos

abnormal pituitary gland development ( J:121843 )

• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

• no apoptosis is observed

abnormal pituitary diverticulum morphology ( J:121843 )

• lumen of Rathke's pouch is absent

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is severely hypoplastic

absent pituitary intermediate lobe ( J:121843 )

• intermediate lobe is absent

nervous system

abnormal pituitary gland morphology ( J:121843 )

• pituitary gland is sphere-shaped

• gland is composed of round cells only and lacks columnar cells

• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC

increased somatotroph cell number ( J:121843 )

• growth hormone-producing cells are slightly increased in number

abnormal neurohypophysis morphology ( J:121843 )

• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals

abnormal pituitary infundibular stalk morphology ( J:121843 )

• at E12.5, evagination of the infundibulum is affected compared to control embryos

abnormal pituitary gland development ( J:121843 )

• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

• no apoptosis is observed

abnormal pituitary diverticulum morphology ( J:121843 )

• lumen of Rathke's pouch is absent

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is severely hypoplastic

absent pituitary intermediate lobe ( J:121843 )

• intermediate lobe is absent