Phenotypes associated with this allele

• Allele Symbol: Cryge^No3
• Allele Name: nuclear opacity 3
• Allele ID: MGI:3713105
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cryge^No3/Cryge^No3	involves: 102/El * C3H/HeH	MGI:3713236
ht2	Cryge^No3/Cryge^+	involves: 102/El * C3H/HeH	MGI:3713234
ht3	Cryge^No3/Cryge^+	involves: 102/El * C3H/HeH * C57BL/6	MGI:3713235

Genotype
MGI:3713236

hm1

• Allelic Composition: Cryge^No3/Cryge^No3
• Genetic Background: involves: 102/El * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:121863 )

• all homozygous mice have cataracts, showing a more severe lens phenotype than heterozygotes

Genotype
MGI:3713234

ht2

• Allelic Composition: Cryge^No3/Cryge⁺
• Genetic Background: involves: 102/El * C3H/HeH

vision/eye

nuclear cataract ( J:121863 )

• all affected animals show a visible nuclear opacity

• Background Sensitivity: when heterozygous animals are derived from crosses to C3H/HeH mice, 53% of animals are affected by cataracts, showing mild diffuse opacities in the lens nucleus; when homozygous mutants are crossed to C3H/HeH mice, essentially all (98.2%) mice show the mild phenotype

Genotype
MGI:3713235

ht3

• Allelic Composition: Cryge^No3/Cryge⁺
• Genetic Background: involves: 102/El * C3H/HeH * C57BL/6

vision/eye

cataract ( J:121863 )

• Background Sensitivity: when heterozygous animals are derived from crosses to C57BL/6 mice, only 28.5% of animals are affected by cataracts, showing mild diffuse opacities in the lens nucleus; this is likely due to incomplete penetrance of this phenotype on this background