Phenotypes associated with this allele

• Allele Symbol: Mfn2^tm2Dcc
• Allele Name: targeted mutation 2, David C Chan
• Allele ID: MGI:3713113
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfn2^tm2Dcc/Mfn2^tm2Dcc	involves: 129S/SvEv	MGI:4442986
hm2	Mfn2^tm2Dcc/Mfn2^tm2Dcc	involves: 129S/SvEv * FVB/N	MGI:3713218

Genotype
MGI:4442986

hm1

• Allelic Composition: Mfn2^tm2Dcc/Mfn2^tm2Dcc
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axonal transport ( J:159219 )

• neurons exhibit disrupted anterograde and retrograde mitochondrial transport compared with wild-type cells

• neurons exhibit fail to exhibit fusion of axonal mitochondria unlike in wild-type mice

• however, transport of other organelles is normal

cellular

abnormal mitochondrial physiology ( J:159219 )

• neurons exhibit disrupted anterograde and retrograde mitochondrial transport compared with wild-type cells

• neurons exhibit fail to exhibit fusion of axonal mitochondria unlike in wild-type mice

• however, transport of other organelles is normal

Genotype
MGI:3713218

hm2

• Allelic Composition: Mfn2^tm2Dcc/Mfn2^tm2Dcc
• Genetic Background: involves: 129S/SvEv * FVB/N

cellular

abnormal mitochondrial morphology ( J:119702 )

• mouse embryonic fibroblasts (MEFs) derived from homozygotes have predominantly tubular mitochondria in contrast to Mfn2-null cells which have extensive mitochondrial fragmentation; no mitochondrial aggregation is observed