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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam17tm1Bbl
targeted mutation 1, Carl P Blobel
MGI:3713365
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam17tm1Bbl/Adam17tm1Bbl involves: 129P2/OlaHsd MGI:3810468
cn2
 		Adam17tm1Bbl/Adam17tm1Bbl
Lyz2tm1(cre)Ifo/0 		involves: 129P2/OlaHsd MGI:3810470
cn3
 		Adam17tm1Bbl/Adam17tm1Bbl
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3810471


Genotype
MGI:3810468
hm1
Allelic
Composition		 Adam17tm1Bbl/Adam17tm1Bbl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation (0 available); any Adam17 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:139846 )
• mice are viable and fertile and do not display any evident pathological phenotype or histopathological defects




Genotype
MGI:3810470
cn2
Allelic
Composition		 Adam17tm1Bbl/Adam17tm1Bbl
Lyz2tm1(cre)Ifo/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation (0 available); any Adam17 mutation (64 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating tumor necrosis factor level ( J:139846 )
• TNF levels in the serum of mice expressing Cre are lower by more than two thirds compared to controls 3 hours after LPS injection

immune system
abnormal macrophage physiology ( J:139846 )
• LPS stimulated release of TNF from macrophages is strongly reduced in these mice
decreased circulating tumor necrosis factor level ( J:139846 )
• TNF levels in the serum of mice expressing Cre are lower by more than two thirds compared to controls 3 hours after LPS injection
decreased susceptibility to endotoxin shock ( J:139846 )
• two weeks after induction of Cre recombinase, mice are more resistant to endotoxin shock than in controls
• 10 of 13 mice survive endotoxin induction with LPS and D-galactosamine while 11 of 13 controls die within 8 hours of injection

hematopoietic system
abnormal macrophage physiology ( J:139846 )
• LPS stimulated release of TNF from macrophages is strongly reduced in these mice




Genotype
MGI:3810471
cn3
Allelic
Composition		 Adam17tm1Bbl/Adam17tm1Bbl
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam17tm1Bbl mutation (0 available); any Adam17 mutation (64 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating tumor necrosis factor level ( J:139846 )
• TNF levels in the serum of mice expressing Cre are lower by more than half compared to controls 3 hours after LPS injection
decreased susceptibility to endotoxin shock ( J:139846 )
• two weeks after induction of Cre recombinase, mice are more resistant to endotoxin shock than in controls
• 6 of 8 mice survive endotoxin induction with LPS and D-galactosamine while 7 of 8 controls die within 16 hours of injection

homeostasis/metabolism
decreased circulating tumor necrosis factor level ( J:139846 )
• TNF levels in the serum of mice expressing Cre are lower by more than half compared to controls 3 hours after LPS injection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory