Phenotypes associated with this allele

• Allele Symbol: Plxnb2^tm1Rkun
• Allele Name: targeted mutation 1, Rohini Kuner
• Allele ID: MGI:3713706
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxnb2^tm1Rkun/Plxnb2^tm1Rkun	involves: FVB/N	MGI:3713710

Genotype
MGI:3713710

hm1

• Allelic Composition: Plxnb2^tm1Rkun/Plxnb2^tm1Rkun
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:121970 )

• no viable mice are produced

nervous system

open neural tube ( J:121970 )

• at E9.5

spina bifida ( J:121970 )

• in 2 of 41 embryos

abnormal brain morphology ( J:121970 )

abnormal cerebellar foliation ( J:121970 )

• at E17.5, only a partially formed cerebellar primordium with an incomplete external granule cell layer (EGL) is present regardless of whether or not embryos developed exencephaly

absent cerebellar foliation ( J:121970 )

• at E18.5, folia are absent

abnormal cerebellum external granule cell layer morphology ( J:121970 )

• incomplete at E17.5

• granule cell progenitors (GCPs) continue to migrate from the rhombic lip

• hypertrophy of the ventricular zone and EGL due to reduced proliferation

abnormal olfactory bulb development ( J:121970 )

• disrupted organization

• lamination is retarded

abnormal brain ventricle morphology ( J:121970 )

• ventricles are enlarged with a thinning of the proliferative zone and multiple ventricle defects regardless of whether or not embryos developed exencephaly

• ventricles are discontinuous at several places accompanied by large protrusions of the neuronal parenchyma into the ventricles

• ventricular ectopias are found in the lateral ventricles

enlarged brain ventricles ( J:121970 )

abnormal choroid plexus morphology ( J:121970 )

• prominent hypertrophy

abnormal striatum morphology ( J:121970 )

• disrupted organization

abnormal diencephalon morphology ( J:121970 )

• in exencephaly embryos, inversed brain topography of the brain consisting of a cortex at the base of the cranium with overlying prominent diencephalic expansion

abnormal cerebellar granule cell morphology ( J:121970 )

• the number of granule cell progenitors (GCPs) in the stream migrating towards the developing dentate gyrus is reduced and migration towards the Ammon's horn is entirely disbanded

• retardation of GCP migration is visible at E17.5

• however, guiding radial cells are present

exencephaly ( J:121970 )

• in 36 of 41 embryos

• in exencephaly embryos, inversed brain topography of the brain consisting of a cortex at the base of the cranium with overlying prominent diencephalic expansion

embryo

open neural tube ( J:121970 )

• at E9.5

spina bifida ( J:121970 )

• in 2 of 41 embryos