Phenotypes associated with this allele

• Allele Symbol: Sirt1^tm1.1Ygu
• Allele Name: targeted mutation 1.1, Yansong Gu
• Allele ID: MGI:3713747
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt1^tm1.1Ygu/Sirt1^tm1.1Ygu	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:3713751

Genotype
MGI:3713751

hm1

• Allelic Composition: Sirt1^tm1.1Ygu/Sirt1^tm1.1Ygu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:121948 )

• some pups generated from male Sirt1^tm1.1Bpr homozygotes crossed with female Sirt1^tm1.1Bpr heterozygotes die around birth

neonatal lethality, incomplete penetrance ( J:121948 )

• two-thirds of mice die shortly after birth

postnatal lethality ( J:121948 )

reproductive system

reproductive system phenotype ( J:121948 )

N • males and females can be fertile

abnormal mammary gland growth during pregnancy ( J:121948 )

♀ • even during pregnancy, ductal morphogenesis is impeded

growth/size/body

decreased body weight ( J:121948 )

postnatal growth retardation ( J:121948 )

endocrine/exocrine glands

abnormal mammary gland morphology ( J:121948 )

♀ • mammary gland development following pregnancy is highly variable ranging from a lack of any ductal structure to a fully developed ductal network

♀ • in pregnancy-induced mammary gland development, alveolar morphogenesis is inadequate

♀ • mammary tissue exhibits increased cell proliferation and apoptosis during late pregnancy and lactation resembling mid-pregnancy levels in wild-type

♀ • successive pregnancies do not improve mammary gland morphogenesis

♀ • however, estrogen treatment restores mammary gland morphogenesis

abnormal branching of the mammary ductal tree ( J:121948 )

♀ • mice have impeded ductal morphogenesis

♀ • in pregnancy-induced mammary gland development, terminal end buds are club-shaped transitional structure

abnormal mammary gland growth during pregnancy ( J:121948 )

♀ • even during pregnancy, ductal morphogenesis is impeded

hypolactation ( J:121948 )

♀ • severe deficit in milk production

integument

abnormal mammary gland morphology ( J:121948 )

♀ • mammary gland development following pregnancy is highly variable ranging from a lack of any ductal structure to a fully developed ductal network

♀ • in pregnancy-induced mammary gland development, alveolar morphogenesis is inadequate

♀ • mammary tissue exhibits increased cell proliferation and apoptosis during late pregnancy and lactation resembling mid-pregnancy levels in wild-type

♀ • successive pregnancies do not improve mammary gland morphogenesis

♀ • however, estrogen treatment restores mammary gland morphogenesis

abnormal branching of the mammary ductal tree ( J:121948 )

♀ • mice have impeded ductal morphogenesis

♀ • in pregnancy-induced mammary gland development, terminal end buds are club-shaped transitional structure

abnormal mammary gland growth during pregnancy ( J:121948 )

♀ • even during pregnancy, ductal morphogenesis is impeded

hypolactation ( J:121948 )

♀ • severe deficit in milk production