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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pggt1btm1.1Mbrg
targeted mutation 1.1, Martin O Bergo
MGI:3713757
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pggt1btm1.1Mbrg/Pggt1btm1.1Mbrg involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3714151
cn2
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441488
cn3
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441490


Genotype
MGI:3714151
hm1
Allelic
Composition		 Pggt1btm1.1Mbrg/Pggt1btm1.1Mbrg
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:122107 )
• cells isolated from an embryo are small and spindle shaped with a dramatic reduction in the amount of polymerized actin
abnormal cell migration ( J:122107 )
• cell migration in a wound healing assay was reduced by 60%-80%




Genotype
MGI:4441488
cn2
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158937 )
• median life span is 170 days
• longer median life span than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice (170 vs. 22 days)

neoplasm
decreased tumor growth/size ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old, compare with lung weight is 10-fold higher in Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age

respiratory system
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age




Genotype
MGI:4441490
cn3
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (208 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:158937 )
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment

respiratory system
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment
abnormal lung epithelium morphology ( J:158937 )
• presence of epithelial hyperplasia after Cre-adenovirus treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory