Phenotypes associated with this allele

• Allele Symbol: Acan^tm2Afos
• Allele Name: targeted mutation 2, Amanda J Fosang
• Allele ID: MGI:3713763
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acan^tm2Afos/Acan^tm2Afos	involves: C57BL/6	MGI:3714116

Genotype
MGI:3714116

hm1

• Allelic Composition: Acan^tm2Afos/Acan^tm2Afos
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased susceptibility to induced arthritis ( J:122102 )

• 4 weeks after destabilization surgery, mice have 40% less structural damage to cartilage than in wild-type mice and by 8 weeks post surgery, the damage is 52% of that seen in wild-type mice

• cartilage erosions in an antigen-induced inflammatory arthritis model are less severe and attempts to repair the damage are evident

immune system

decreased susceptibility to induced arthritis ( J:122102 )

• 4 weeks after destabilization surgery, mice have 40% less structural damage to cartilage than in wild-type mice and by 8 weeks post surgery, the damage is 52% of that seen in wild-type mice

• cartilage erosions in an antigen-induced inflammatory arthritis model are less severe and attempts to repair the damage are evident