Phenotypes associated with this allele

• Allele Symbol: Lepr^tm2Mgmj
• Allele Name: targeted mutation 2, Martin G Myers, Jr
• Allele ID: MGI:3713767
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^tm2Mgmj/Lepr^tm2Mgmj	B6.Cg-Lepr^tm2Mgmj	MGI:3713769
hm2	Lepr^tm2Mgmj/Lepr^tm2Mgmj	Not Specified	MGI:3837370
ht3	Lepr^tm2Mgmj/Lepr^+	B6.Cg-Lepr^tm2Mgmj	MGI:3713770

Genotype
MGI:3713769

hm1

• Allelic Composition: Lepr^tm2Mgmj/Lepr^tm2Mgmj
• Genetic Background: B6.Cg-Lepr^tm2Mgmj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:122056 )

• in young females fed ad libitum or older females on a high fat diet

decreased circulating leptin level ( J:122056 )

• in males and females

adipose tissue

abnormal fat pad morphology ( J:122056 )

• fat pads are decreased in females regardless of diet

decreased gonadal fat pad weight ( J:122056 )

• gonadal fat pad weight in older female mice is decreased

growth/size/body

decreased body weight ( J:122056 )

• female weight in older mice is decreased on a normal or high fat diet

Genotype
MGI:3837370

hm2

• Allelic Composition: Lepr^tm2Mgmj/Lepr^tm2Mgmj
• Genetic Background: Not Specified

endocrine/exocrine glands

decreased insulin secretion ( J:145998 )

• leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets

homeostasis/metabolism

decreased insulin secretion ( J:145998 )

• leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets

Genotype
MGI:3713770

ht3

• Allelic Composition: Lepr^tm2Mgmj/Lepr⁺
• Genetic Background: B6.Cg-Lepr^tm2Mgmj

homeostasis/metabolism

decreased circulating insulin level ( J:122056 )

• in young females fed ad libitum or older females on a high fat diet