Analysis Tools
mortality/aging
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• by 60 days, 6 of 7 mice are dead or moribund while 8 of 9 wild-type mice survived pass 120 days
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• Background Sensitivity: 90% of mice die prior to weaning whereas lethality was 100% on a pure 129/SvEv background or a mixed 129S6 and C57BL/6 background
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reproductive system
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• spermatids are disorganized and reduced in number
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• primary spermocytes are disorganized and reduced in number
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• one third of pachytene staged cells exhibit an asynapsis of the XY chromosome and only 9 of 195 nuclei have a univalent XY
• meiotic recombination does not occur
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• at 12 weeks, maturing ovarian follicles are absent and there is a mild proliferation of interstitial cells
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• at 12 weeks, maturing ovarian follicles are absent
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small ovary
(
J:122058
)
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small testis
(
J:122058
)
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immune system
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• lymphopenia
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• immature (B220+CD43-) B cells are reduced in the bone marrow and spleen
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• slight
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• mature (IgMhiIgDhi) B cells are reduced in the bone marrow and spleen
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• pre-B cell compartment in the bone marrow is reduced
• progenitor cells fail to differentiate into pr-B cells in vitro but differentiation of other lineages is normal
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growth/size/body
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• mice are smaller at birth and remain so
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cellular
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• spermatids are disorganized and reduced in number
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• primary spermocytes are disorganized and reduced in number
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• enlarged
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• one third of pachytene staged cells exhibit an asynapsis of the XY chromosome and only 9 of 195 nuclei have a univalent XY
• meiotic recombination does not occur
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• in vitro
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skeleton
muscle
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• atrophy of the muscle accompanying atrophied fat pads in the skin
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adipose tissue
endocrine/exocrine glands
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• at 12 weeks, maturing ovarian follicles are absent and there is a mild proliferation of interstitial cells
|
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• at 12 weeks, maturing ovarian follicles are absent
|
small ovary
(
J:122058
)
|
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small testis
(
J:122058
)
|
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hematopoietic system
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• lymphopenia
|
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• immature (B220+CD43-) B cells are reduced in the bone marrow and spleen
|
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• slight
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• mature (IgMhiIgDhi) B cells are reduced in the bone marrow and spleen
|
|
• pre-B cell compartment in the bone marrow is reduced
• progenitor cells fail to differentiate into pr-B cells in vitro but differentiation of other lineages is normal
|
integument
homeostasis/metabolism
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• by 60 days, 6 of 7 mice are dead or moribund while 8 of 9 wild-type mice survived pass 120 days
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