Analysis Tools
mortality/aging
|
• mice begin to die at day 9 or 10 and no mice survive past day 16
|
cardiovascular system
|
• decreased in thickness
|
|
• at day 1, mice have a 1.2 times higher ratio of heart weight to body weight compared with wild-type and the ratio progressively increases to 1.7 and 2.2 times higher at day 7 and 10
|
|
• at 10 days, mice have a modest degree of cardiac fibrosis
|
|
• reduced fractional shortening occurs
|
|
• left ventricular end-diastolic and -systolic dimensions are larger
|
|
• at 7 and 10 days, heart rates are slower
|
growth/size/body
|
• at day 1, mice have a 1.2 times higher ratio of heart weight to body weight compared with wild-type and the ratio progressively increases to 1.7 and 2.2 times higher at day 7 and 10
|
|
• body weight is decreased by 10% in 7- and 10-day mice compared to that of normal mice
• however, body weight is normal at day 1
|
muscle
|
• reduced fractional shortening occurs
|
|
• left ventricular end-diastolic and -systolic dimensions are larger
|
