Phenotypes associated with this allele

• Allele Symbol: Ace^tm6Keb
• Allele Name: targeted mutation 6, Kenneth E Bernstein
• Allele ID: MGI:3713781
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm6Keb/Ace^tm6Keb	involves: 129 * C57BL/6	MGI:3714013
hm2	Ace^tm6Keb/Ace^tm6Keb	involves: 129 * C57BL/6 * CD-1	MGI:3714015
ht3	Ace^tm6Keb/Ace^+	involves: 129 * C57BL/6	MGI:3714014

Genotype
MGI:3714013

hm1

• Allelic Composition: Ace^tm6Keb/Ace^tm6Keb
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:122178 )

• the number of white blood cells in tumor blood vessels is increased and includes monocyte-like and phagocytic cells

decreased tumor growth/size ( J:122178 )

• Background Sensitivity: after infection with B16-F10 melanoma cells, tumor size is reduced on a 129/C57BL/6 background to 90+/-18mm³ compared to 540+/-83mm³ in wild-type mice

• reduced tumor size is observed following infection with B16-LS9 cells or mouse lymphoma cell line EL4

• however, treatment with captopril or anti-CD8+ antibodies reverts tumor growth to wild-type size

immune system

increased T cell number ( J:122178 )

• CD8+ T cell numbers are increased following exposure to two B16-F10-specific epitopes or mouse lymphoma cell line EL4

abnormal interleukin level ( J:122178 )

• IL-12 levels are increased following treatment with LPs or LPS and interferon-gamma

• IL-10 levels are decreased following treatment with melanoma cells or LPS

hematopoietic system

increased T cell number ( J:122178 )

• CD8+ T cell numbers are increased following exposure to two B16-F10-specific epitopes or mouse lymphoma cell line EL4

homeostasis/metabolism

abnormal interleukin level ( J:122178 )

• IL-12 levels are increased following treatment with LPs or LPS and interferon-gamma

• IL-10 levels are decreased following treatment with melanoma cells or LPS

Genotype
MGI:3714015

hm2

• Allelic Composition: Ace^tm6Keb/Ace^tm6Keb
• Genetic Background: involves: 129 * C57BL/6 * CD-1

neoplasm

decreased tumor growth/size ( J:122178 )

• Background Sensitivity: after infection with B16-F10 melanoma cells, tumor size is reduced on a CD-1 background to 104+/-33mm³ compared to 552+/-134mm³ in wild-type mice

Genotype
MGI:3714014

ht3

• Allelic Composition: Ace^tm6Keb/Ace⁺
• Genetic Background: involves: 129 * C57BL/6

neoplasm

decreased tumor growth/size ( J:122178 )

• after infection with B16-F10 melanoma cells, tumor size is reduced to 252+/-43mm³ compared to 540+/-83mm³ in wild-type mice