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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irs2tm1.1With
targeted mutation 1.1, Dominic J Withers
MGI:3713784
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irs2tm1.1With/Irs2tm1.1With B6.129S6-Irs2tm1.1With MGI:3713797


Genotype
MGI:3713797
hm1
Allelic
Composition		 Irs2tm1.1With/Irs2tm1.1With
Genetic
Background		 B6.129S6-Irs2tm1.1With
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2tm1.1With mutation (0 available); any Irs2 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased granulosa cell proliferation ( J:122064 )
• granulosa cell proliferation is defective

reproductive system
decreased granulosa cell proliferation ( J:122064 )
• granulosa cell proliferation is defective
abnormal corpus luteum morphology ( J:122064 )
• oocytes are sometimes trapped in the corpora lutea
abnormal ovarian follicle morphology ( J:122064 )
• ovaries have increased numbers of atretic follicles, reduced numbers of large antral follicles and an absence of preovulatory follicles
decreased tertiary ovarian follicle number ( J:122064 )
• ovaries have reduced numbers of large antral follicles
increased atretic ovarian follicle number ( J:122064 )
• ovaries have increased numbers of atretic follicles
abnormal ovarian folliculogenesis ( J:122064 )
• although early folliculogenesis is normal later stages are reduced in size
• granulosa cells do not proceed to a rapid phase of proliferation as in wild-type mice
absent mature ovarian follicles ( J:122064 )
• absence of preovulatory follicles
polyovular ovarian follicle ( J:122064 )
• follicles occasionally contain double oocytes

endocrine/exocrine glands
decreased granulosa cell proliferation ( J:122064 )
• granulosa cell proliferation is defective
abnormal corpus luteum morphology ( J:122064 )
• oocytes are sometimes trapped in the corpora lutea
abnormal ovarian follicle morphology ( J:122064 )
• ovaries have increased numbers of atretic follicles, reduced numbers of large antral follicles and an absence of preovulatory follicles
decreased tertiary ovarian follicle number ( J:122064 )
• ovaries have reduced numbers of large antral follicles
increased atretic ovarian follicle number ( J:122064 )
• ovaries have increased numbers of atretic follicles
abnormal ovarian folliculogenesis ( J:122064 )
• although early folliculogenesis is normal later stages are reduced in size
• granulosa cells do not proceed to a rapid phase of proliferation as in wild-type mice
absent mature ovarian follicles ( J:122064 )
• absence of preovulatory follicles
polyovular ovarian follicle ( J:122064 )
• follicles occasionally contain double oocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory