cellular
|
• granulosa cell proliferation is defective
|
reproductive system
|
• granulosa cell proliferation is defective
|
|
• oocytes are sometimes trapped in the corpora lutea
|
|
• ovaries have increased numbers of atretic follicles, reduced numbers of large antral follicles and an absence of preovulatory follicles
|
|
• ovaries have reduced numbers of large antral follicles
|
|
• ovaries have increased numbers of atretic follicles
|
|
• although early folliculogenesis is normal later stages are reduced in size
• granulosa cells do not proceed to a rapid phase of proliferation as in wild-type mice
|
|
• absence of preovulatory follicles
|
|
• follicles occasionally contain double oocytes
|
endocrine/exocrine glands
|
• granulosa cell proliferation is defective
|
|
• oocytes are sometimes trapped in the corpora lutea
|
|
• ovaries have increased numbers of atretic follicles, reduced numbers of large antral follicles and an absence of preovulatory follicles
|
|
• ovaries have reduced numbers of large antral follicles
|
|
• ovaries have increased numbers of atretic follicles
|
|
• although early folliculogenesis is normal later stages are reduced in size
• granulosa cells do not proceed to a rapid phase of proliferation as in wild-type mice
|
|
• absence of preovulatory follicles
|
|
• follicles occasionally contain double oocytes
|