Analysis Tools
immune system
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• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
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• increase in frequency of plasma cells in the B cell population (4.96% of B cells compared to 0.04% in controls)
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• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
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• cell surface mIgM and mIgD are reduced 50% in B cells and B cells express reduced CD93, CD95, and CD80 indicating a loss of anergic B cells
• B cells lose features of anergy, including antigen unresponsiveness measured by BCR aggregation-induced Akt activation and calcium mobilization
• increase in frequency of B cells with activated phenotype (CD86+)
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• mice spontaneously express about 4-fold increased autoantibody by 20 weeks of age
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hematopoietic system
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• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
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• increase in frequency of plasma cells in the B cell population (4.96% of B cells compared to 0.04% in controls)
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• peripheral B cell numbers are reduced by about 70%, suggesting enhanced negative selection
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