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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alkbh2tm1Klng
targeted mutation 1, Arne Klungland
MGI:3714064
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Alkbh2tm1Klng/Alkbh2tm1Klng involves: C57BL/6J MGI:3714950
cx2
 		Alkbh2tm1Klng/Alkbh2tm1Klng
Alkbh3tm1Klng/Alkbh3tm1Klng 		involves: C57BL/6J MGI:3714951


Genotype
MGI:3714950
hm1
Allelic
Composition		 Alkbh2tm1Klng/Alkbh2tm1Klng
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alkbh2tm1Klng mutation (0 available); any Alkbh2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:108782 )
N
• mice appear healthy and viable up to 18 months of age

cellular
abnormal DNA repair ( J:108782 )
• in absence of exogenous exposure to methylating agents, mice accumulate significant levels of 1-methyladenine in their genomes compared to wild-type or Alkbh3-deficient mice, detectable at 4 months and increasing by 8 months, due to inefficient DNA repair
• repair kinetics of 1-methyladenine lesions in DNA exposed to a methylating agent are much lower than in wild-type with only a small fraction of 1-methyladenine being repaired after 36 hours

homeostasis/metabolism
abnormal DNA repair ( J:108782 )
• in absence of exogenous exposure to methylating agents, mice accumulate significant levels of 1-methyladenine in their genomes compared to wild-type or Alkbh3-deficient mice, detectable at 4 months and increasing by 8 months, due to inefficient DNA repair
• repair kinetics of 1-methyladenine lesions in DNA exposed to a methylating agent are much lower than in wild-type with only a small fraction of 1-methyladenine being repaired after 36 hours




Genotype
MGI:3714951
cx2
Allelic
Composition		 Alkbh2tm1Klng/Alkbh2tm1Klng
Alkbh3tm1Klng/Alkbh3tm1Klng
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alkbh2tm1Klng mutation (0 available); any Alkbh2 mutation (71 available)
Alkbh3tm1Klng mutation (0 available); any Alkbh3 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:108782 )
N
• mice appear healthy and viable up to 12 months of age

cellular
abnormal DNA repair ( J:108782 )
• DNA repair kinetics of 1-methyladenine lesions are similar to Alkbh2-deficient cells

homeostasis/metabolism
abnormal DNA repair ( J:108782 )
• DNA repair kinetics of 1-methyladenine lesions are similar to Alkbh2-deficient cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory