Phenotypes associated with this allele

• Allele Symbol: Slc32a1^tm1Yyan
• Allele Name: targeted mutation 1, Yuchio Yanagawa
• Allele ID: MGI:3714155
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc32a1^tm1Yyan/Slc32a1^tm1Yyan	Not Specified	MGI:3714842

Genotype
MGI:3714842

hm1

• Allelic Composition: Slc32a1^tm1Yyan/Slc32a1^tm1Yyan
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:122055 )

craniofacial

cleft palate ( J:122055 )

nervous system

abnormal nervous system electrophysiology ( J:122055 )

• no respiratory discharges are recorded from the C4 ventral roots at E18 (4-18/minute in wild-type)

• at E14-15, discharges are very infrequent (0.59/minute) from C4, in comparison to wild-type (1.85/minute)

• nonrespiratory body-movement related discharges from ventral roots which are larger and are accompanied by a long-lasting trough are observed

abnormal nerve fiber response ( J:122055 )

• single neurons from rostrolateral medulla generate intermittent or continuous action potentials

• noradrenaline and substance P do not induce discharges in C4 ventral roots; substance P increases spike frequency of intermittently firing neurons but does not affect frequency in actively firing neurons

• strychnine has no effect on mutant neurons compared to effect seen on wild-type or Gad1/Gad2-null neurons

abnormal inhibitory postsynaptic potential ( J:122055 )

• neurons show spontaneous EPSPs but not IPSPs

respiratory system

primary atelectasis ( J:122055 )

respiratory failure ( J:122055 )

• when animals are delivered at E18, homozygotes do not start autonomous breathing, unlike wild-type, and physical manipulation of the animals does not induce any respiration-like movements

digestive/alimentary system

cleft palate ( J:122055 )

growth/size/body

cleft palate ( J:122055 )

omphalocele ( J:122055 )