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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Commd1tm1Bvds
targeted mutation 1, Bart van de Sluis
MGI:3714157
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Commd1tm1Bvds/Commd1tm1Bvds involves: 129S/SvEv MGI:3714158
hm2
 		Commd1tm1Bvds/Commd1tm1Bvds involves: 129S/SvEv * C57BL/6 MGI:3714159


Genotype
MGI:3714158
hm1
Allelic
Composition		 Commd1tm1Bvds/Commd1tm1Bvds
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd1tm1Bvds mutation (0 available); any Commd1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:122208 )
• pups are recovered at E9.5 but few are recovered at E10.5 and only one at E11.5

embryo
abnormal embryo turning ( J:122208 )
• no axial rotation is observed
embryonic growth retardation ( J:122208 )
• at E8.5 and E9.5
• however, no gross morphological defects are observed at E9.5
decreased embryo size ( J:122208 )
• at E8.5 and E9.5, pups are small
abnormal mesenchyme morphology ( J:122208 )
• at E9.5, increased apoptosis is observed in the mesenchymal cells in the developing brain
abnormal placenta vasculature ( J:122208 )
• no vascularization is observed in the placenta
abnormal allantois morphology ( J:122208 )
• allantois is fused to the chorionic plate
abnormal chorionic plate morphology ( J:122208 )
• allantois is fused to the chorionic plate

nervous system
abnormal brain development ( J:122208 )
• at E9.5, increased apoptosis is observed in the mesenchymal cells in the developing brain

growth/size/body
embryonic growth retardation ( J:122208 )
• at E8.5 and E9.5
• however, no gross morphological defects are observed at E9.5
decreased embryo size ( J:122208 )
• at E8.5 and E9.5, pups are small

cardiovascular system
abnormal placenta vasculature ( J:122208 )
• no vascularization is observed in the placenta




Genotype
MGI:3714159
hm2
Allelic
Composition		 Commd1tm1Bvds/Commd1tm1Bvds
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd1tm1Bvds mutation (0 available); any Commd1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:122208 )
• Background Sensitivity: no mice are born on a C57BL/6 background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory