Phenotypes associated with this allele

• Allele Symbol: Chuk^tm1.1Mpa
• Allele Name: targeted mutation 1.1, Manolis Pasparakis
• Allele ID: MGI:3714161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chuk^tm1.1Mpa/Chuk^tm1.1Mpa	involves: C57BL/6	MGI:3714172

Genotype
MGI:3714172

hm1

• Allelic Composition: Chuk^tm1.1Mpa/Chuk^tm1.1Mpa
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:122320 )

• pups die perinatally

skeleton

abnormal skeleton morphology ( J:122320 )

• including deformed heads, thoracic cavity, tails and limbs, cleft palate, visible presphenoid and vomer, unfused xiphoid process, syndactyly with fused phalanges and missing second/third phalanges at front and hind paws

abnormal presphenoid bone morphology ( J:122320 )

• visible

abnormal vomer bone morphology ( J:122320 )

• visible

abnormal xiphoid process morphology ( J:122320 )

• unfused

limbs/digits/tail

abnormal limb morphology ( J:122320 )

• skeletal deformation

abnormal tail morphology ( J:122320 )

• skeletal deformation

craniofacial

abnormal presphenoid bone morphology ( J:122320 )

• visible

abnormal vomer bone morphology ( J:122320 )

• visible

cleft palate ( J:122320 )

digestive/alimentary system

cleft palate ( J:122320 )

integument

abnormal epidermal layer morphology ( J:122320 )

• pups have a thick undifferentiated epidermis that engulfs the limbs in a cocoon-like fashion

abnormal keratinocyte differentiation ( J:122320 )

• primary keratinocytes do not differentiate in medium with increased calcium as wild-type ones do

abnormal epidermis stratum basale morphology ( J:122320 )

• proliferation in the basal layer cells is increased

thick epidermis ( J:122320 )

cellular

abnormal keratinocyte differentiation ( J:122320 )

• primary keratinocytes do not differentiate in medium with increased calcium as wild-type ones do

growth/size/body

abnormal head morphology ( J:122320 )

• skeletal deformation

cleft palate ( J:122320 )