About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Maml1tm1Mkit
targeted mutation 1, Motoo Kitagawa
MGI:3714162
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Maml1tm1Mkit/Maml1tm1Mkit involves: 129P2/OlaHsd * C57BL/6 MGI:3714826
cx2
 		Maml1tm1Mkit/Maml1tm1Mkit
Maml3tm1Mkit/Maml3tm1Mkit 		B6.129P2-Maml3tm1Mkit Maml1tm1Mkit MGI:5301733
cx3
 		Maml1tm1Mkit/Maml1tm1Mkit
Maml3tm1Mkit/Maml3tm1Mkit 		involves: 129P2/OlaHsd * C57BL/6 MGI:5301732


Genotype
MGI:3714826
hm1
Allelic
Composition		 Maml1tm1Mkit/Maml1tm1Mkit
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maml1tm1Mkit mutation (1 available); any Maml1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Maml1tm1Mkit/Maml1tm1Mkit mice are growth retarded

mortality/aging
postnatal lethality, incomplete penetrance ( J:122286 )
• smaller mice die prior to weaning

immune system
decreased thymocyte number ( J:122286 )
• at E17.5-E18.5, the number of thymocytes is 4-fold smaller than in controls
• at P7 and P8, thymocyte number is decreased 12-fold
increased double-negative T cell number ( J:122286 )
• at E17.5-E18.5, the number of double negative cells is increased 3- to 4-fold
• at P7 and P8, the number of double negative cells is increased 2- to 3-fold
decreased marginal zone B cell number ( J:122286 )
• the number of marginal zone cells is decreased in spleen

growth/size/body
decreased body weight ( J:122286 )
• after 1 week of birth mice are 3- to 4-fold smaller by appearance and weight than normal mice or heterozygotes
postnatal growth retardation ( J:122286 )

muscle

hematopoietic system
decreased thymocyte number ( J:122286 )
• at E17.5-E18.5, the number of thymocytes is 4-fold smaller than in controls
• at P7 and P8, thymocyte number is decreased 12-fold
increased double-negative T cell number ( J:122286 )
• at E17.5-E18.5, the number of double negative cells is increased 3- to 4-fold
• at P7 and P8, the number of double negative cells is increased 2- to 3-fold
decreased marginal zone B cell number ( J:122286 )
• the number of marginal zone cells is decreased in spleen

endocrine/exocrine glands
decreased thymocyte number ( J:122286 )
• at E17.5-E18.5, the number of thymocytes is 4-fold smaller than in controls
• at P7 and P8, thymocyte number is decreased 12-fold




Genotype
MGI:5301733
cx2
Allelic
Composition		 Maml1tm1Mkit/Maml1tm1Mkit
Maml3tm1Mkit/Maml3tm1Mkit
Genetic
Background		 B6.129P2-Maml3tm1Mkit Maml1tm1Mkit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maml1tm1Mkit mutation (1 available); any Maml1 mutation (26 available)
Maml3tm1Mkit mutation (0 available); any Maml3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:178680 )
• Background Sensitivity: lethality begins earlier compared to mice on a mixed 129P2/OlaHsd and C57BL/6 background
• underrepresented at E10.5 and absent by E11.5




Genotype
MGI:5301732
cx3
Allelic
Composition		 Maml1tm1Mkit/Maml1tm1Mkit
Maml3tm1Mkit/Maml3tm1Mkit
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maml1tm1Mkit mutation (1 available); any Maml1 mutation (26 available)
Maml3tm1Mkit mutation (0 available); any Maml3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:178680 )
• survive up to E12.5
• Background Sensitivity: embryos survive longer compared to mice on an inbred C57BL/6 background

embryo
abnormal pharyngeal arch morphology ( J:178680 )
• at E9.5 to E10.5 embryos have a single branchial arch
decreased embryo size ( J:178680 )
• most embryos are smaller than littermate controls at E9.5 to E10.5
abnormal visceral yolk sac morphology ( J:178680 )
• at E9.5 to E10.5 the yolk sac has a rough texture and the vessels are barely visible

cardiovascular system
abnormal angiogenesis ( J:178680 )
• at E9.5 to E10.5 blood vessels are present but the structure is more primitive and less finely branched in the head region
abnormal heart looping ( J:178680 )
• poorly folded hearts are often seen in embryos at E9.5 to E10.5
enlarged pericardium ( J:178680 )
• often seen in embryos at E9.5 to E10.5

nervous system
abnormal neuron proliferation ( J:178680 )
• accelerated neurogenesis in the neural tube, forebrain and hindbrain

craniofacial
abnormal pharyngeal arch morphology ( J:178680 )
• at E9.5 to E10.5 embryos have a single branchial arch

growth/size/body
decreased embryo size ( J:178680 )
• most embryos are smaller than littermate controls at E9.5 to E10.5

cellular
abnormal neuron proliferation ( J:178680 )
• accelerated neurogenesis in the neural tube, forebrain and hindbrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory