mortality/aging
• two (from 31 litters) survived to 3 weeks
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• die within one day of birth
(J:122275)
• die within 1 day of birth except two (from 31 litters) survive to 3 weeks
(J:122606)
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growth/size/body
• smaller than littermates
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nervous system
• smaller cerebellar plate at the hindbrain
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• enlarged interventricular foramen that connects the lateral ventricles with the third ventricle in the forebrain at E15.5
• form a gap in the ventral midline area at the forebrain
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• enlarged fourth ventricle at the hindbrain
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• smaller medulla oblongata at the hindbrain
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• reduced septum in the forebrain at E15.5
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• enlarged lateral ventricles in the forebrain at E15.5
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behavior/neurological
• severe ataxia in mice survive to 3 weeks
• unable to maintain their balance and show poorly coordinated movement
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