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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ebf2tm2(Zfp423)Reed
targeted mutation 2, Randall R Reed
MGI:3714341
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ebf2tm2(Zfp423)Reed/Ebf2tm2(Zfp423)Reed Not Specified MGI:3714639
cn2
 		Ebf2tm2(Zfp423)Reed/Ebf2+
Omptm4(cre)Mom/Omp+ 		involves: 129 * 129P2/OlaHsd * C57BL/10J MGI:5461577
cn3
 		Ebf2tm2(Zfp423)Reed/Ebf2+
Omptm4(cre)Mom/Omp+ 		involves: 129P2/OlaHsd MGI:3714638


Genotype
MGI:3714639
hm1
Allelic
Composition		 Ebf2tm2(Zfp423)Reed/Ebf2tm2(Zfp423)Reed
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:122275 )
• mice display a wild-type phenotype




Genotype
MGI:5461577
cn2
Allelic
Composition		 Ebf2tm2(Zfp423)Reed/Ebf2+
Omptm4(cre)Mom/Omp+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired neuron differentiation ( J:190934 )
• impaired olfactory sensory neuron differentiation
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

taste/olfaction
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

cellular
impaired neuron differentiation ( J:190934 )
• impaired olfactory sensory neuron differentiation

craniofacial
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

respiratory system
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

growth/size/body
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons




Genotype
MGI:3714638
cn3
Allelic
Composition		 Ebf2tm2(Zfp423)Reed/Ebf2+
Omptm4(cre)Mom/Omp+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

craniofacial
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

respiratory system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

growth/size/body
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory