About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ebf2tm2.1(Zfp423)Reed
targeted mutation 2.1, Randall R Reed
MGI:3714342
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+ involves: 129 * C57BL/10J MGI:5461574
ht2
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+ Not Specified MGI:3714636
cx3
 		Ebf2tm2.1(Zfp423)Reed/Ebf2+
Omptm1Mom/Omp+ 		involves: 129S2/SvPas MGI:3714637


Genotype
MGI:5461574
ht1
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic
Background		 involves: 129 * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired neuron differentiation ( J:190934 )
• apparent arrest of olfactory sensory neuron differentiation
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

taste/olfaction
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

cellular
impaired neuron differentiation ( J:190934 )
• apparent arrest of olfactory sensory neuron differentiation

craniofacial
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

respiratory system
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

growth/size/body
abnormal olfactory epithelium morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons
abnormal olfactory sensory neuron morphology ( J:190934 )
• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons




Genotype
MGI:3714636
ht2
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons
abnormal olfactory bulb morphology ( J:122275 )
• the dorsal olfactory bulb surface is largely devoid of glomeruli and few projecting axons reaching the dorsal surface migrating along aberrant paths instead of converging
• the olfactory bulb lack an extensive olfactory neuronal layer and glomerular layer at the dorsal and lateral olfactory bulb surface
• however, some glomeruli remain on the medial surface
• axonal growth occurs but the majority fail to innervate the bulb
abnormal olfactory nerve morphology ( J:122275 )
• the dorsal surface of the olfactory bulb lacks an olfactory nerve layer

growth/size/body
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons
decreased body size ( J:122275 )

respiratory system
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

craniofacial
abnormal olfactory epithelium morphology ( J:122275 )
• fewer number of mature cells due to an increase in apoptosis
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons




Genotype
MGI:3714637
cx3
Allelic
Composition		 Ebf2tm2.1(Zfp423)Reed/Ebf2+
Omptm1Mom/Omp+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm2.1(Zfp423)Reed mutation (0 available); any Ebf2 mutation (30 available)
Omptm1Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

craniofacial
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

respiratory system
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons

growth/size/body
abnormal olfactory sensory neuron morphology ( J:122275 )
• fewer number of mature olfactory receptor neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory