All Phenotypes C6<Q0> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

C6^Q0
C6 deficiency in Peru-Coppock site strain
MGI:3714381

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C6^Q0/C6^Q0	C3.Cg-C6^Q0	MGI:3714382
cx2	Apoe^tm1Bres/Apoe^tm1Bres C6^Q0/C6^Q0	involves: 129P2/OlaHsd	MGI:5298860

Allelic Composition	C6^Q0/C6^Q0
Genetic Background	C3.Cg-C6^Q0

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C6^Q0 mutation (1 available); any C6 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:120567 )

• mice are resistant to ischemia reperfusion-induced renal injury

• serum urea nitrogen is reduced 31% to 55% compared to wild-type mice subjected to ischemia reperfusion

• neutrophil infiltration at the site of injury was reduced

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres C6^Q0/C6^Q0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (11 available); any Apoe mutation (148 available)
C6^Q0 mutation (1 available); any C6 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:158457 )

• mice fed a high-fat diet exhibit decreased atherosclerotic plaque formation and total vessel area affected compared with Apoe^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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