All Phenotypes Gab2<tm1Gsf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gab2^tm1Gsf
targeted mutation 1, Gen-Sheng Feng
MGI:3714456

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab2^tm1Gsf/Gab2^tm1Gsf	involves: BALB/c	MGI:3714660

Allelic Composition	Gab2^tm1Gsf/Gab2^tm1Gsf
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab2^tm1Gsf mutation (0 available); any Gab2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to infection ( J:122213 )

• in an in vivo experiment, Friend virus (FV) infection fail to trigger Epo-independent colony formation

decreased susceptibility to Retroviridae infection ( J:122429 )

• Background Sensitivity: spleen size following Friend erythroleukemia virus (FV) infection is not as inflamed as in wild-type mice on a FV2 sensitive background

• however, mice do not have changed response from that of the FV2 resistant strain background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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