Phenotypes associated with this allele

• Allele Symbol: Nkd1^tm1Kwha
• Allele Name: targeted mutation 1, Keith Wharton
• Allele ID: MGI:3714460
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkd1^tm1Kwha/Nkd1^tm1Kwha	involves: 129S/SvEv	MGI:3714498
hm2	Nkd1^tm1Kwha/Nkd1^tm1Kwha	involves: 129S/SvEv * C57BL/6	MGI:3714496
ht3	Nkd1^tm1Kwha/Nkd1^+	involves: 129S/SvEv	MGI:3714500
ht4	Nkd1^tm1Kwha/Nkd1^+	involves: 129S/SvEv * C57BL/6	MGI:3714499
cx5	Nkd1^tm1Kwha/Nkd1^+ Nkd2^tm1Kwha/Nkd2^+	involves: 129S/SvEv * C57BL/6	MGI:3714515
cx6	Nkd1^tm1Kwha/Nkd1^tm1Kwha Nkd2^tm1Kwha/Nkd2^tm1Kwha	involves: 129S/SvEv * C57BL/6	MGI:3714516

Genotype
MGI:3714498

hm1

• Allelic Composition: Nkd1^tm1Kwha/Nkd1^tm1Kwha
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced fertility ( J:122353 )

• Background Sensitivity: homozygous matings produce fewer litters (6 mating pairs - 1 litter) on 129/SvEv background compared to those of homozygotes on mixed background (6 mating pairs - 19 litters)

decreased litter size ( J:122353 )

• Background Sensitivity: mean litter size of homozygous intercrosses is reduced (1 pup) compared to litters observed on mixed background (5.3 pups) or litters of heterozygous intercrosses regardless of genetic background (4.9-7.3 pups)

skeleton

skeleton phenotype ( J:122353 )

N • Background Sensitivity: skeletons show no consistent differences relative to wild-type in terms of bone mass or morphology

Genotype
MGI:3714496

hm2

• Allelic Composition: Nkd1^tm1Kwha/Nkd1^tm1Kwha
• Genetic Background: involves: 129S/SvEv * C57BL/6

growth/size/body

short nasal bone ( J:122353 )

• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background

postnatal growth retardation ( J:122353 )

• Background Sensitivity: 4- to 12-week old pups fed ad libitum show a slight but significant growth retardation (15% in males at 12 weeks, 4.6% in females at 12 weeks) compared to wild-type mice

reproductive system

reproductive system phenotype ( J:122353 )

N • Background Sensitivity: mice are viable and fertile; average litter size is 7.3

N • 3-month old males had similar testis-to-body weight as controls and normal spermatogenesis

craniofacial

short nasal bone ( J:122353 )

• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background

skeleton

short nasal bone ( J:122353 )

• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background

respiratory system

short nasal bone ( J:122353 )

• Background Sensitivity: nasal bones are slightly shortened relative to controls or homozygotes on the mixed background

Genotype
MGI:3714500

ht3

• Allelic Composition: Nkd1^tm1Kwha/Nkd1⁺
• Genetic Background: involves: 129S/SvEv

reproductive system

reproductive system phenotype ( J:122353 )

N • mice are viable and fertile

Genotype
MGI:3714499

ht4

• Allelic Composition: Nkd1^tm1Kwha/Nkd1⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

reproductive system

reproductive system phenotype ( J:122353 )

N • mice are viable and fertile

Genotype
MGI:3714515

cx5

• Allelic Composition: Nkd1^tm1Kwha/Nkd1⁺; Nkd2^tm1Kwha/Nkd2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

behavior/neurological

pup cannibalization ( J:122353 )

♀ • significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)

Genotype
MGI:3714516

cx6

• Allelic Composition: Nkd1^tm1Kwha/Nkd1^tm1Kwha; Nkd2^tm1Kwha/Nkd2^tm1Kwha
• Genetic Background: involves: 129S/SvEv * C57BL/6

reproductive system

reproductive system phenotype ( J:122353 )

N • mice are viable and fertile

behavior/neurological

pup cannibalization ( J:122353 )

♀ • significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)

craniofacial

decreased cranium height ( J:122353 )

• at 2 months, skulls of mice are slightly shortened

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

skeleton

decreased cranium height ( J:122353 )

• at 2 months, skulls of mice are slightly shortened

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

growth/size/body

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

respiratory system

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls