Phenotypes associated with this allele

• Allele Symbol: Dp(4D4Mit190-D4Mit51)1Aam
• Allele Name: duplication, Chr 4, Alea A Mills 1
• Allele ID: MGI:3714526
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam	involves: 129S7/SvEvBrd	MGI:3714605
cx2	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53^+	involves: 129S7/SvEvBrd	MGI:3714608
cx3	Dp(4D4Mit190-D4Mit51)1Aam/0 Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd	MGI:3714609
ot4	Dp(4D4Mit190-D4Mit51)1Aam/0	involves: 129S7/SvEvBrd	MGI:3714603

Genotype
MGI:3714605

cx1

• Allelic Composition: Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121726 )

• mice are indistinguishable from wild-type mice

Genotype
MGI:3714608

cx2

• Allelic Composition: Dp(4D4Mit190-D4Mit51)1Aam/0; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

preweaning lethality, incomplete penetrance ( J:121726 )

• some mice die prior to weaning

embryo

abnormal embryo development ( J:121726 )

• defects in development are less severe than in Dp(4D4Mit190-D4Mit51)1AAM heterozygotes

growth/size/body

decreased body size ( J:121726 )

• some mice are runted

behavior/neurological

ataxia ( J:121726 )

• some mice develop ataxia

Genotype
MGI:3714609

cx3

• Allelic Composition: Dp(4D4Mit190-D4Mit51)1Aam/0; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:121726 )

• mice are viable

Genotype
MGI:3714603

ot4

• Allelic Composition: Dp(4D4Mit190-D4Mit51)1Aam/0
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

perinatal lethality ( J:121726 )

cellular

abnormal mitosis ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have greater a numbers of cells in G2/M (25.9% compared to 16.9% in wild-type cells)

increased neural tube apoptosis ( J:121726 )

• mice have increased apoptosis in neural tube cells

decreased cell proliferation ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have reduced proliferative potential compared to wild-type cells with greater numbers of cells in G2/M (25.9% compared to 16.9% in wild-type cells)

early cellular replicative senescence ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos exhibit earlier senescence

limbs/digits/tail

abnormal tail development ( J:121726 )

• conspicuous curling of the tail late in development

curly tail ( J:121726 )

nervous system

increased neural tube apoptosis ( J:121726 )

• mice have increased apoptosis in neural tube cells

exencephaly ( J:121726 )

vision/eye

microphthalmia ( J:121726 )