Phenotypes associated with this allele

• Allele Symbol: Del(4D4Mit190-D4Mit51)2Aam
• Allele Name: deletion, chr 4, Alea A Mills 2
• Allele ID: MGI:3714527
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(4D4Mit190-D4Mit51)2Aam/Del(4D4Mit190-D4Mit51)2Aam	involves: 129S7/SvEvBrd	MGI:3714604
ht2	Del(4D4Mit190-D4Mit51)2Aam/+	involves: 129S7/SvEvBrd	MGI:3714601
cx3	Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam	involves: 129S7/SvEvBrd	MGI:3714605

Genotype
MGI:3714604

hm1

• Allelic Composition: Del(4D4Mit190-D4Mit51)2Aam/Del(4D4Mit190-D4Mit51)2Aam
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:121726 )

Genotype
MGI:3714601

ht2

• Allelic Composition: Del(4D4Mit190-D4Mit51)2Aam/+
• Genetic Background: involves: 129S7/SvEvBrd

cellular

abnormal mitosis ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have fewer cells in G2/M (11.9% compared to 16.9% in wild-type cells)

increased fibroblast proliferation ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos have enhanced proliferative potential compared to wild-type cells with fewer cells in G2/M (11.9% compared to 16.9% in wild-type cells)

delayed cellular replicative senescence ( J:121726 )

• mouse embryonic fibroblast from E13.5 embryos exhibit delayed senescence, are sensitive to immortalization and form foci instead of being limited to a monolayer

neoplasm

increased lymphoma incidence ( J:121726 )

• 2 of 4 adult mice examined develop lymphomas

increased squamous cell carcinoma incidence ( J:121726 )

• in adults, squamous cell carcinoma occurred in one animal

digestive/alimentary system

esophageal epithelium hyperplasia ( J:121726 )

• in adults, gastroesophageal epithelial hyperplasia occurs

hematopoietic system

spleen hyperplasia ( J:121726 )

• in adults

immune system

spleen hyperplasia ( J:121726 )

• in adults

renal/urinary system

abnormal renal/urinary system morphology ( J:121726 )

• in adults, genitourinary hyperplasia occurs

reproductive system

uterus hyperplasia ( J:121726 )

♀ • in adults, uterine hyperplasia occurs

growth/size/body

spleen hyperplasia ( J:121726 )

• in adults

Genotype
MGI:3714605

cx3

• Allelic Composition: Dp(4D4Mit190-D4Mit51)1Aam/Del(4D4Mit190-D4Mit51)2Aam
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:121726 )

• mice are indistinguishable from wild-type mice