Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Ngb,-EGFP)1Dgrn
• Allele Name: transgene insertion 1, David Greenberg
• Allele ID: MGI:3714625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Ngb,-EGFP)1Dgrn/Tg(CAG-Ngb,-EGFP)1Dgrn	involves: C57BL/6 * CD-1 * DBA/2	MGI:3714626

Genotype
MGI:3714626

tg1

• Allelic Composition: Tg(CAG-Ngb,-EGFP)1Dgrn/Tg(CAG-Ngb,-EGFP)1Dgrn
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased myocardial infarct size ( J:117158 )

• transmural infarct affecting left ventricle, produced by occlusion of left anterior descending coronary artery (LADA), is ~25% smaller (as percentage of left ventricle volume or percentage of LADA territory) than in controls

nervous system

decreased cerebral infarct size ( J:117158 )

• MCA occlusion results in an ipsilateral infarct affecting the striatum and cerebral cortex that is ~30% smaller than the lesion produced in wild-type brains

homeostasis/metabolism

decreased myocardial infarct size ( J:117158 )

• transmural infarct affecting left ventricle, produced by occlusion of left anterior descending coronary artery (LADA), is ~25% smaller (as percentage of left ventricle volume or percentage of LADA territory) than in controls

abnormal nitric oxide homeostasis ( J:117158 )

• myocardial tissue sections from transgenic animals show markedly increased endothelial nitric oxide synthase (eNOS) immunoreactivity and increased eNOS protein expression by Western blot compared to wild-type myocardium

decreased cerebral infarct size ( J:117158 )

• MCA occlusion results in an ipsilateral infarct affecting the striatum and cerebral cortex that is ~30% smaller than the lesion produced in wild-type brains